FGFR1OP

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[1][2][3]

Function

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[3]

References

  1. Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ (February 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
  2. Reither A, Hehlmann R, Goldman JM, Cross NC (April 1999). "[The 8p11 myeloproliferative syndrome]". Medizinische Klinik. 94 (4): 207–10. PMID 10373756.
  3. 3.0 3.1 "Entrez Gene: FGFR1OP FGFR1 oncogene partner".

Further reading

External links

  • Media related to [[commons:Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).|Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).]] at Wikimedia Commons