FBLN2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.[1][2]

This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

Interactions

FBLN2 has been shown to interact with Laminin, alpha 1,[3][4] Laminin, alpha 5[3] and Perlecan.[5][6]

References

  1. Zhang RZ, Pan TC, Zhang ZY, Mattei MG, Timpl R, Chu ML (January 1995). "Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes". Genomics. 22 (2): 425–30. doi:10.1006/geno.1994.1404. PMID 7806230.
  2. 2.0 2.1 "Entrez Gene: FBLN2 fibulin 2".
  3. 3.0 3.1 Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. UNITED STATES. 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. ISSN 0021-9258. PMID 9006922.
  4. Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. UNITED STATES. 275 (45): 35192–9. doi:10.1074/jbc.M003261200. ISSN 0021-9258. PMID 10934193.
  5. Hopf, M; Göhring W; Mann K; Timpl R (August 2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan". J. Mol. Biol. England. 311 (3): 529–41. doi:10.1006/jmbi.2001.4878. ISSN 0022-2836. PMID 11493006.
  6. Sasaki, T; Göhring W; Pan T C; Chu M L; Timpl R (December 1995). "Binding of mouse and human fibulin-2 to extracellular matrix ligands". J. Mol. Biol. ENGLAND. 254 (5): 892–9. doi:10.1006/jmbi.1995.0664. ISSN 0022-2836. PMID 7500359.

Further reading




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