FAP (gene)

Fibroblast activation protein, alpha
PDB rendering based on 1z68.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1z68​
Identifiers
Symbols	FAP ; DPPIV; DKFZp686G13158; FAPA; SEPRASE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48282
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fibroblast activation protein, alpha, also known as FAP, is a human gene.

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Further reading

• Rettig WJ, Su SL, Fortunato SR; et al. (1994). "Fibroblast activation protein: purification, epitope mapping and induction by growth factors". Int. J. Cancer. 58 (3): 385–92. PMID 7519584.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mathew S, Scanlan MJ, Mohan Raj BK; et al. (1995). "The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23". Genomics. 25 (1): 335–7. PMID 7774951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Raj BK, Calvo B; et al. (1994). "Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5657–61. PMID 7911242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Piñeiro-Sánchez ML, Goldstein LA, Dodt J; et al. (1997). "Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease". J. Biol. Chem. 272 (12): 7595–601. PMID 9065413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goldstein LA, Ghersi G, Piñeiro-Sánchez ML; et al. (1997). "Molecular cloning of seprase: a serine integral membrane protease from human melanoma". Biochim. Biophys. Acta. 1361 (1): 11–9. PMID 9247085.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goldstein LA, Chen WT (2000). "Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform". J. Biol. Chem. 275 (4): 2554–9. PMID 10644713.
• Ghersi G, Dong H, Goldstein LA; et al. (2002). "Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex". J. Biol. Chem. 277 (32): 29231–41. doi:10.1074/jbc.M202770200. PMID 12023964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy MT, McCaughan GW, Marinos G, Gorrell MD (2002). "Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection". Liver. 22 (2): 93–101. PMID 12028401.CS1 maint: Multiple names: authors list (link)
• Artym VV, Kindzelskii AL, Chen WT, Petty HR (2002). "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton". Carcinogenesis. 23 (10): 1593–601. PMID 12376466.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorrell MD, Wang XM, Levy MT; et al. (2003). "Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection". Adv. Exp. Med. Biol. 524: 235–43. PMID 12675244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin X, Iwasa S, Okada K; et al. (2003). "Expression patterns of seprase, a membrane serine protease, in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Res. 23 (4): 3195–8. PMID 12926053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwasa S, Jin X, Okada K; et al. (2003). "Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer". Cancer Lett. 199 (1): 91–8. PMID 12963128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goodman JD, Rozypal TL, Kelly T (2003). "Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells". Clin. Exp. Metastasis. 20 (5): 459–70. PMID 14524536.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada K, Chen WT, Iwasa S; et al. (2004). "Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer". Oncology. 65 (4): 363–70. doi:10.1159/000074650. PMID 14707457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng JD, Valianou M, Canutescu AA; et al. (2005). "Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth". Mol. Cancer Ther. 4 (3): 351–60. doi:10.1158/1535-7163.MCT-04-0269. PMID 15767544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aertgeerts K, Levin I, Shi L; et al. (2005). "Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha". J. Biol. Chem. 280 (20): 19441–4. doi:10.1074/jbc.C500092200. PMID 15809306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fassnacht M, Lee J, Milazzo C; et al. (2006). "Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy". Clin. Cancer Res. 11 (15): 5566–71. doi:10.1158/1078-0432.CCR-05-0699. PMID 16061874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)