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An E-box is a DNA sequence which usually lies upstream of a gene in a promoter region. The consensus sequence for the E-box element is CANNTG, with a palindromic canonical sequence of CACGTG.[1] Transcription factors containing the basic-helix-loop-helix protein structural motif typically bind to E-boxes or related variant sequences and enhance transcription of the downstream gene.

Proteins that interact with E-boxes


  1. Chaudhary, Jaideep. "Basic Helix-Loop-Helix Proteins Can Act at the E-Box within the Serum Response Element of the c-fos Promoter to Influence Hormone-Induced Promoter Activation in Sertoli Cells". Molecular Endocrinology. 12 (5): 774–786. Unknown parameter |coauthors= ignored (help)