Downstream transcription factor II B recognition element gene transcriptions

Editor-In-Chief: Henry A. Hoff

File:Loris lydekkerianus nordicus 003.jpg

This image is of a gray slender loris (Loris lydekkerianus nordicus) from Northern Sri Lanka. Credit: Dr. K.A.I. Nekaris.

Template:TOCright The downstream B recognition element designated as the BRE^d,^[1] or dBRE, is an additional core promoter element that occurs downstream of the TATA box and is recognized by general transcription factor II B.^[1]

Consensus sequences

A consensus sequence is 5'-A/G-T-A/G/T-G/T-G/T-G/T-G/T-3' or in the transcription direction on the template strand 3'-A/G-T-A/G/T-G/T-G/T-G/T-G/T-5'.^[1]

Eukaryote genes

Of 140 promoters from the eukaryotic promoter database, "[S]ix percent ... [contain] at least six out of seven bases of the consensus sequence, 18% contain at least five of seven bases and 37% contain at least four of seven".^[1]

Human genes

GeneID: 9555 H2A histone family, member Y (H2AFY)^[2] "contains a poor TATA element, but both a consensus Inr and DPE in addition to a six/seven match BRE^d."^[1]

General transcription factor II Bs

A TFIIB recognition element (BRE) functions to determine the orientation of the TFIIB-TBP-TATA complex that projects the zinc ribbon of TFIIB toward the TSS.^[3]

General transcription factor II B can recognize two distinct sequence elements that flank the TATA box.^[1] "The selected sequences contain a strong representation of [ guanine (G) and thymine (T)] bases and a striking preference against [ adenine (A)] (especially between bases -17 and -20)."^[1]

"[T]here are ... some weakly conserved features including the TFIIB-Recognition Element (BRE), approximately 5 nucleotides upstream (BRE^u) and 5 nucleotides downstream (BRE^d) of the TATA box.^[4]"^[5]

The TFIIB-DNA contact with the BRE^d takes place via the minor groove, while that with the upstream B recognition element (BRE^u) takes place through the major groove.^[1]

Transcription start sites

dBRE is cis-TATA box, between the TATA box and the Inr or transcription start site (TSS) and trans-TSS.^[1]

Hypotheses

The dBRE is not involved in the transcription of A1BG.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Wensheng Deng, Stefan G.E. Roberts (2005). "A core promoter element downstream of the TATA box that is recognized by TFIIB". Genes & Development. 19 (20): 2418–23. doi:10.1101/gad.342405. PMID 16230532. Unknown parameter |month= ignored (help); Unknown parameter |pdf= ignored (help)
↑ HGNC (February 10, 2013). "H2AFY H2A histone family, member Y [ Homo sapiens ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2013-02-11.
↑ Tsai FTP, Sigler PB (2000). "Structural basis of preinitiation complex assembly on human Pol II promoters". EMBO J. 19: 25–36.
↑ "Polymerase II".
↑ "RNA polymerase II holoenzyme, In: Wikipedia". San Francisco, California: Wikimedia Foundation, Inc. January 19, 2013. Retrieved 2013-02-11.

External links

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Downstream transcription factor II B recognition element gene transcriptions

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