Discriminant function

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Discriminant function (also called modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

<math>\left [{4}.{6}\times\ prothombin\ time\ -\ control\ value\ (seconds)\right ]\ +\ serum\ bilirubin\ (mg/dl)\,</math>

Prospective studies have shown that, it is useful in predicting short term prognosis especially mortality within 30 days. A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%.

See also

• Model for End-Stage Liver Disease
• Child-Pugh score