Digoxin
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Synonyms / Brand Names:
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Dosing and Administration
Because the pharmacokinetics of Digoxin are complex, and because toxic levels of Digoxin are only slightly higher than therapeutic levels, Digoxin dosing can be difficult. The recommended approach is to:
- estimate the patient’s daily maintenance dose;
- adjust the estimate to account for patient-specific factors;
- choose a dosing regimen;
- monitor the patient for toxicity and for therapeutic effect, if possible; and
- adjust the dose.
Estimated daily maintenance dose
- Children > 2 years old - daily oral dose 10 mcg/kg/day
- Prepubertal children - daily oral dose 10 mcg/kg/day
- Adults - daily oral dose 3 mcg/kg/day
These doses will, in uncomplicated patients, tend to produce steady-state post-absorptive levels of 1 to 2 ng/mL, but the confidence limits around this range are wide.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Digoxin
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Publication Resources
Most Recent Articles on Digoxin
Review Articles on Digoxin
Articles on Digoxin in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Digoxin
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Trial Resources
Ongoing Trials with Digoxin at Clinical Trials.gov
Trial Results with Digoxin
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Digoxin
Cochrane Collaboration on Digoxin
Cost Effectiveness of Digoxin
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Media Resources
Powerpoint Slides on Digoxin
Images of Digoxin
Podcasts & MP3s on Digoxin
Videos on Digoxin
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Digoxin
Discussion Groups on Digoxin
Patient Handouts on Digoxin
Blogs on Digoxin
Digoxin in the News
Digoxin in the Marketplace
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International Resources
Digoxin en Español
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The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
