dCTP diphosphatase

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In enzymology, a dCTP diphosphatase (EC is an enzyme that catalyzes the chemical reaction

dCTP + H2O dCMP + diphosphate

Thus, the two substrates of this enzyme are dCTP and H2O, whereas its two products are dCMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase. Other names in common use include deoxycytidine-triphosphatase, dCTPase, dCTP pyrophosphatase, deoxycytidine triphosphatase, deoxy-CTPase, and dCTPase. This enzyme participates in pyrimidine metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Zimmerman SB and Kornberg A (1961). "Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli". J. Biol. Chem. 236: 1480&ndash, 1486.

External links

The CAS registry number for this enzyme class is 9024-87-7.

Gene Ontology (GO) codes