Cushing's syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

Cushing's disease can lead to The symptoms of Cushing's syndrome usually start with symptoms such as rapid weight gain, a round face often referred to as a "moon face", and insomnia. It may progress to develop amenorrhoea, infertility and psychological disturbances. If left untreated, patients with Cushing's syndrome may progress to develop diabetes, cardiovascular and psychiatric complications. The prognosis depends on the severity of the disease.

Natural History

The symptoms of Cushing's syndrome usually start with symptoms such as rapid weight gain, a round face often referred to as a "moon face", and insomnia. It may progress to develop amenorrhoea, infertility, and psychological disturbances. If left untreated, patients with Cushing's syndrome may progress to develop diabetes mellitus and cardiovascular complications.

Complications

Cushing's syndrome can lead to the following complications:[1][2]

Prognosis

The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of tumors may recur. Mortality in patients with Cushing's syndrome is increased even after the apparently successful treatment.[3]

References

  1. Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015). "Cushing's syndrome". Lancet. 386 (9996): 913–27. doi:10.1016/S0140-6736(14)61375-1. PMID 26004339.
  2. "Increased risk of osteoporotic fractures in patients with Cushing's syndrome".
  3. Lodish M (2015). "Cushing's syndrome in childhood: update on genetics, treatment, and outcomes". Curr Opin Endocrinol Diabetes Obes. 22 (1): 48–54. doi:10.1097/MED.0000000000000127. PMC 4415092. PMID 25517021.


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