Cushing's syndrome medical therapy

Jump to: navigation, search

Cushing's syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cushing's syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cushing's syndrome medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cushing's syndrome medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cushing's syndrome medical therapy

CDC on Cushing's syndrome medical therapy

Cushing's syndrome medical therapy in the news

Blogs on Cushing's syndrome medical therapy

Directions to Hospitals Treating Cushing's syndrome

Risk calculators and risk factors for Cushing's syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The medications usually used for the treatment of Cushing's syndrome are Pasireotide, Cabergoline, Ketoconazole and Metyrapone. The choice of medical therapy should be individualized. It is guided by drug efficacy, side effects, individual patient factors, and cost.

Medical therapy

Indications for medical treatment of Cushing's syndrome include:[1]

The medications usually used for the treatment of Cushing's syndrome are:[2]

The choice of medical therapy should be individualized. It is guided by drug efficacy, side effects, individual patient factors, and cost.[3]

Drug regimen

Drug regimens used for the treatment of Cushing's syndrome are: [2]

  • Drug regimen 1: Ketoconazole 400–1600 mg per day orally
  • Drug regimen 2: Mifepristone 300–1200 mg per day orally
  • Drug regimen 3: Metyrapone 0·5–4·5 g per day orally
  • Drug regimen 4: Pasireotide 750–2400 μg per day subcutaneously injected
  • Drug regimen 5: Cabergoline Up to 7 mg per week orally
  • Drug regimen 6: Mitotane 3–5 g per day orally


It is important to remember that the vast majority of cases of Cushing's syndrome are caused by steroid medications (such causes are described as iatrogenic) so a review of medications first, as stopping or reducing the dose can usually resolve the problem.

References

  1. van der Pas R, de Herder WW, Hofland LJ, Feelders RA (2012). "New developments in the medical treatment of Cushing's syndrome". Endocr. Relat. Cancer. 19 (6): R205–23. doi:10.1530/ERC-12-0191. PMID 22936543.
  2. 2.0 2.1 Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015). "Cushing's syndrome". Lancet. 386 (9996): 913–27. doi:10.1016/S0140-6736(14)61375-1. PMID 26004339.
  3. "Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic".




Linked-in.jpg