Cronkhite–Canada disease

Cronkhite–Canada disease

WikiDoc Resources for Cronkhite–Canada disease
Articles
Most recent articles on Cronkhite–Canada disease Most cited articles on Cronkhite–Canada disease Review articles on Cronkhite–Canada disease Articles on Cronkhite–Canada disease in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Cronkhite–Canada disease Images of Cronkhite–Canada disease Photos of Cronkhite–Canada disease Podcasts & MP3s on Cronkhite–Canada disease Videos on Cronkhite–Canada disease
Evidence Based Medicine
Cochrane Collaboration on Cronkhite–Canada disease Bandolier on Cronkhite–Canada disease TRIP on Cronkhite–Canada disease
Clinical Trials
Ongoing Trials on Cronkhite–Canada disease at Clinical Trials.gov Trial results on Cronkhite–Canada disease Clinical Trials on Cronkhite–Canada disease at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Cronkhite–Canada disease NICE Guidance on Cronkhite–Canada disease NHS PRODIGY Guidance FDA on Cronkhite–Canada disease CDC on Cronkhite–Canada disease
Books
Books on Cronkhite–Canada disease
News
Cronkhite–Canada disease in the news Be alerted to news on Cronkhite–Canada disease News trends on Cronkhite–Canada disease
Commentary
Blogs on Cronkhite–Canada disease
Definitions
Definitions of Cronkhite–Canada disease
Patient Resources / Community
Patient resources on Cronkhite–Canada disease Discussion groups on Cronkhite–Canada disease Patient Handouts on Cronkhite–Canada disease Directions to Hospitals Treating Cronkhite–Canada disease Risk calculators and risk factors for Cronkhite–Canada disease
Healthcare Provider Resources
Symptoms of Cronkhite–Canada disease Causes & Risk Factors for Cronkhite–Canada disease Diagnostic studies for Cronkhite–Canada disease Treatment of Cronkhite–Canada disease
Continuing Medical Education (CME)
CME Programs on Cronkhite–Canada disease
International
Cronkhite–Canada disease en Espanol Cronkhite–Canada disease en Francais
Business
Cronkhite–Canada disease in the Marketplace Patents on Cronkhite–Canada disease
Experimental / Informatics
List of terms related to Cronkhite–Canada disease

Overview

Cronkhite–Canada disease is a rare syndrome characterised by multiple polyps of the digestive tract. It is sporadic (i.e. it does not seem to be a hereditary disease), and it is currently considered idiopathic (i.e. cause remains unknown).

Presentation

Polyps are most frequent in the stomach and large intestine, are also found in the small intestine, and are least frequent in the oesophagus. A biopsy will reveal them to be hamartomas; the possibility that they progress to cancer is generally considered to be low, although it has been reported multiple times in the past. Chronic diarrhoea and protein-losing enteropathy are often observed. Possible collateral features include variable anomalies of ectodermal tissues, such as alopecia, atrophy of the nails, or skip pigmentation of the skin.

Cronkhite-Canada syndrome is a rare disease affecting mainly patients between 50-60 years of age, characterised by skin changes and gastrointestinal distrubances. Patients present with epidermal changes such as hair loss, nail loss, and hyperpigmentation. There can also be varying degrees of malabsorption, malnutrition, hematochezia, and in some cases, colorectal cancer.

Cause

The cause of the disease is unknown. It was originally thought that the epidermal changes were secondary to profound malnutrition as a result of protein-losing enteropathy. Recent findings have called this hypothesis into question; specifically, the hair and nail changes may not improve with improved nutrition.

Treatment

Treatments proposed include cromolyn sodium and prednisone.

See also

Other conditions consisting of multiple hamartomatous polyps of the digestive tract include Peutz-Jeghers syndrome, juvenile polyposis, and Cowden disease.

External links

• "Cronkite-Canada syndrome".

See also

Other conditions consisting of multiple hamartomatous polyps of the digestive tract include Peutz-Jeghers syndrome, juvenile polyposis, and Cowden disease.

References

• PMID 16148564 "Is Cronkhite–Canada Syndrome necessarily a late-onset disease?", Eur J Gastroenterol Hepatol. 2005 Oct;17(10):1139–41
• PMID 12868681 "Adenocarcinoma and multiple adenomas of the large intestine, associated with Cronkhite–Canada syndrome", Dig Liver Dis. 2003 Jun;35(6):434–8
• PMID 11846261 "Medical management of Cronkhite–Canada syndrome", South Med J. 2002 Feb;95(2):272–4
• PMID 11310396 "Cronkhite Canada syndrome", J Assoc Physicians India. 2000 Nov;48(11):1116–8
• PMID 8076560 "The Cronkhite–Canada syndrome: a seldom recognized entity", Endoscopy. 1994 Mar;26(3):331–2
• PMID 2552848 "Hepathology of Cronkhite–Canada polyps. A comparison to juvenile polyposis", Am J Surg Pathol. 1989 Nov;13(11):940–6
• PMID 3745857 "Colon cancer in the Cronkhite–Canada syndrome", J Clin Gastroenterol. 1986
• PMID 5022956 "Diffuse gastrointestinal polyposis with ectodermal changes: Cronkhite–Canada syndrome", Radiology. 1972 Jun;103(3):589–94
• PMID 4099144 "Alopecia areata in association with intestinal polyposis. The relationship of two syndromes—Gardner's and Cronkhite–Canada", Acta Derm Venereol. 1970;50(5):381–4
• PMID 4964743 "Case of cronkhite–Canada syndrome with associated jejunal diverticulosis", Br Med J. 1967 Dec 9;4(5579):601–2.