Creutzfeldt-Jakob disease diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The diagnosis of Creutzfeldt Jakob disease depends on a combination of positive findings from physical examination and laboratory testing. Based on the findings, the diagnosis of Creutzfeldt Jakob disease may be either probable or possible. There are no definitive criteria for the diagnosis of Creutzfeldt Jakob disease.

Diagnostic Criteria for a Probable Diagnosis

Diagnosis of Creutzfeldt Jakob disease is probable if following criteria are fulfilled:

  • Rapidly progressive dementia plus at least any 2 of the following features

PLUS

  • Positive result on one of the following laboratory tests:

PLUS

  • No alternative diagnosis is suspected on routine investigation.[1]

Diagnostic Criteria for a Possible Diagnosis

Diagnosis of Creutzfeldt Jakob disease is possible if following criteria are fulfilled:

  • Rapidly progressive dementia plus at least any 2 of the following features

PLUS

  • Absence of a positive result for any of the three laboratory tests that would classify a case as probable (see above).

PLUS

  • Duration of illness is less than two years.

PLUS

  • No alternative diagnosis is suspected on routine investigation.[1]

References

  1. 1.0 1.1 "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in |title= (help)

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