Clara cell

Jump to: navigation, search

WikiDoc Resources for Clara cell

Articles

Most recent articles on Clara cell

Most cited articles on Clara cell

Review articles on Clara cell

Articles on Clara cell in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Clara cell

Images of Clara cell

Photos of Clara cell

Podcasts & MP3s on Clara cell

Videos on Clara cell

Evidence Based Medicine

Cochrane Collaboration on Clara cell

Bandolier on Clara cell

TRIP on Clara cell

Clinical Trials

Ongoing Trials on Clara cell at Clinical Trials.gov

Trial results on Clara cell

Clinical Trials on Clara cell at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Clara cell

NICE Guidance on Clara cell

NHS PRODIGY Guidance

FDA on Clara cell

CDC on Clara cell

Books

Books on Clara cell

News

Clara cell in the news

Be alerted to news on Clara cell

News trends on Clara cell

Commentary

Blogs on Clara cell

Definitions

Definitions of Clara cell

Patient Resources / Community

Patient resources on Clara cell

Discussion groups on Clara cell

Patient Handouts on Clara cell

Directions to Hospitals Treating Clara cell

Risk calculators and risk factors for Clara cell

Healthcare Provider Resources

Symptoms of Clara cell

Causes & Risk Factors for Clara cell

Diagnostic studies for Clara cell

Treatment of Clara cell

Continuing Medical Education (CME)

CME Programs on Clara cell

International

Clara cell en Espanol

Clara cell en Francais

Business

Clara cell in the Marketplace

Patents on Clara cell

Experimental / Informatics

List of terms related to Clara cell


Clara cells are non-mucous and non-ciliated secretory cells found in the primary bronchioles of the lungs.

Clara cells are dome-shaped and have short microvilli. One of the main functions of Clara cells is to protect the bronchiolar epithelium. They do this by secreting a small variety of products, including Clara cell secretory protein (CCSP) and a component of the lung surfactant. They are also responsible for detoxifying harmful substances inhaled into the lungs. Clara cells accomplish this with cytochrome P450 enzymes found in their smooth endoplasmic reticulum. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.

Clara cells were originally described by their namesake, Max Clara in 1937.

The respiratory bronchioles represent the transition from the conducting portion to the respiratory portion of the respiratory system. The narrow channels are usually less than 2 mm in diameter and they are lined by a simple cuboidal epithelium, consisting of ciliated cells and non-ciliated Clara cells, which are unique to bronchioles. In addition to being structurally diverse, Clara cells are also functionally variable. One major function they carry out is the synthesis and secretion of the material lining the bronchiolar lumen. This material includes glycosaminoglycans, and proteins such as antibodies and lysosymes. These play an important defensive role, and they also contribute to the degradation of the mucus produced by the upper airways. The heterogeneous nature of the dense granules within the Clara cell's cytoplasm suggests that they may not all have a secretory function. Some of them may contain lysosomal enzymes, which carry out a digestive role, either in defense: Clara cells engulf airborne toxins and break them down via their cytochrome P-450 enzymes present in their smooth endoplasmic reticulum; or in the recycling of secretory products. Clara cells are mitotically active cells. They divide and differentiate to form both ciliated and non-ciliated epithelial cells.

See also

References

  • Dudek, Ronald W. High-Yield Histology, 3rd ed. (2004). ISBN 0-7817-4763-5
  • Gartner, Leslie P. and James L. Hiatt. Color Textbook of Histology, 2nd ed. (2001). ISBN 0-7216-8806-3
  • "Zur Histobiologie des Bronchialepithels." Z. mikrosk.-anat. Forsch. 4: 321-347.

External links


Linked-in.jpg