Citrate-CoA ligase

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In enzymology, a citrate-CoA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + citrate + CoA ADP + phosphate + (3S)-citryl-CoA

The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citrate cycle (tca cycle).


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  • Lill U, Schreil A, Eggerer H (1982). "Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase". Eur. J. Biochem. 125: 645&ndash, 50. PMID 6749502.
  • Aoshima M, Ishii M, Igarashi Y (2004). "A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 52: 751&ndash, 61. PMID 15101981.

External links

The CAS registry number for this enzyme class is 856428-87-0.

Gene Ontology (GO) codes