Celecoxib overdose
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Overdose topics
General
No overdoses of CELEBREX were reported during clinical trials. Doses up to 2400 mg/day for up to 10
days in 12 patients did not result in serious toxicity. Symptoms following acute NSAID overdoses are
usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally
reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure,
respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported
with therapeutic ingestion of NSAIDs, and may occur following an overdose. Return to top
Treatment
Patients should be managed by symptomatic and supportive care following an NSAID overdose.
There are no specific antidotes. No information is available regarding the removal of celecoxib by
hemodialysis, but based on its high degree of plasma protein binding (>97%) dialysis is unlikely to be
useful in overdose. Emesis and/or activated charcoal (60 to 100 g in adults, 1 to 2 g/kg in children)
and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms
or following a large overdose. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion
may not be useful due to high protein binding. Return to top
The content of this page is taken from the FDA package insert for this drug and should not be edited.
