Cathepsin K
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| Image:Cathepsin K 1TU6.png | |
| Ribbon diagram of cathepsin K, colored by secondary structure. From PDB 1TU6. | |
| cathepsin K
| |
| Identifiers | |
| Symbol | CTSK |
| Alt. Symbols | CTSO2, CTSO, PYCD |
| Entrez | 1513 |
| HUGO | 2536 |
| OMIM | 601105 |
| RefSeq | NM_000396 |
| UniProt | P43235 |
| Other data | |
| Locus | Chr. 1 q21 |
Cathepsin K, which is defined by its high specificity for kinins, is involved in bone resorption.
Cathepsin K's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in Emphysema. Cathepsin K "blockers" show great potential in the treatment of osteoporosis. Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury.
Additional images
External links
| This hydrolase article is a stub. You can help WikiDoc by expanding it. |
Hydrolase: proteases (EC 3.4) | |
|---|---|
| Exopeptidase 3.4.11-19 | Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II) |
| Endopeptidase 3.4.21-24 | Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases |
| Cathepsin 3.4.18,21,22,23 | A - B - C - K |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
