Cathepsin F

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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
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Cathepsin F is a protein that in humans is encoded by the CTSF gene.[1][2][3]

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. In general, cathepsins contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251-amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids that contains a 19-residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.[3]


  1. Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D (Dec 1998). "Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization". J Biol Chem. 273 (48): 32000–8. doi:10.1074/jbc.273.48.32000. PMID 9822672.
  2. Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C (Jun 1999). "Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain". J Biol Chem. 274 (20): 13800–9. doi:10.1074/jbc.274.20.13800. PMID 10318784.
  3. 3.0 3.1 "Entrez Gene: CTSF cathepsin F".

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: C01.018