Captopril challenge test

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In medicine, the captopril challenge test, also CCT, is a non-invasive test used to help diagnose renal artery stenosis.

The CCT, in adults, has a high sensitivity, but a low specificity.^[1] A better test for diagnosing renal artery stenosis is subtraction renal angiography.^[2]

How it is done

The CCT is performed by measuring the renin prior to and following the administration of captopril, an angiotensin converting enzyme inhibitor. A CCT is considered positive if the renin levels increase substaintially or the baseline renin level is abnormally high.^[3]

Use of the CCT in children

The CCT has not been found to be very useful in children.^[4]

References

1. ↑ Bales A. Hypertensive crisis. How to tell if it's an emergency or an urgency. Postgrad Med. 1999 May 1;105(5):119-26, 130. PMID 10335324. Free Full Text.
2. ↑ Svetkey LP, Himmelstein SI, Dunnick NR, Wilkinson RH Jr, Bollinger RR, McCann RL, Beytas EM, Klotman PE. Prospective analysis of strategies for diagnosing renovascular hypertension. Hypertension. 1989 Sep;14(3):247-57. PMID 2670763.
3. ↑ Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, Preibisz JJ, Laragh JH. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986 Apr;80(4):633-44. PMID 3515933.
4. ↑ Gauthier B, Trachtman H, Frank R, Pillari G. Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents. Pediatr Nephrol. 1991 Jan;5(1):42-4. PMID 2025535.

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Articles on Captopril challenge test	Most recent articles on Captopril challenge test • Most cited articles on Captopril challenge test • Review articles on Captopril challenge test • Articles on Captopril challenge test in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Captopril challenge test	Powerpoint slides on Captopril challenge test • Images of Captopril challenge test • Photos of Captopril challenge test • Podcasts & MP3s on Captopril challenge test • Videos on Captopril challenge test
Evidence Based Medicine Regarding Captopril challenge test	Cochrane Collaboration on Captopril challenge test • Bandolier on Captopril challenge test • TRIP on Captopril challenge test
Cost Effectiveness of Captopril challenge test	Cost Effectiveness of Captopril challenge test
Clinical Trials Involving Captopril challenge test	Ongoing Trials on Captopril challenge test at Clinical Trials.gov • Trial results on Captopril challenge test • Clinical Trials on Captopril challenge test at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Captopril challenge test	US National Guidelines Clearinghouse on Captopril challenge test • NICE Guidance on Captopril challenge test • NHS PRODIGY Guidance • FDA on Captopril challenge test • CDC on Captopril challenge test
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Genetics, Pharmacogenomics, and Proteinomics of Captopril challenge test	Genetics of Captopril challenge test • Pharmacogenomics of Captopril challenge test • Proteomics of Captopril challenge test
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