Captopril challenge test

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In medicine, the captopril challenge test, also CCT, is a non-invasive test used to help diagnose renal artery stenosis.

The CCT, in adults, has a high sensitivity, but a low specificity.[1] A better test for diagnosing renal artery stenosis is subtraction renal angiography.[1]

How it is done

The CCT is performed by measuring the renin prior to and following the administration of captopril, an angiotensin converting enzyme inhibitor. A CCT is considered positive if the renin levels increase substaintially or the baseline renin level is abnormally high.[1]

Use of the CCT in children

The CCT has not been found to be very useful in children.[1]

References

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