Canals of Hering
|Canals of Hering|
They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. Histologically, the cells of the ductule are described as simple cuboidal epithelium, lined partially by cholangiocytes and hepatocytes. They may not be readily visible but can be differentially stained by cytokeratins CK19 and CK7.
The Canals of Hering are destroyed early in biliary cirrhosis and may be primary sites of scarring in methotrexate toxicity. Research have indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states.
- Ross, M.H. & Pawlina, W. 2003. Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia.
- Gartner, L.P. & Hiatt, J.L. 2000. Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
- Saxena, R. & Theise, N. 2004. Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48.
- synd/6168 at Who Named It