CST8 (gene)

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Cystatin-8 is a protein that in humans is encoded by the CST8 gene.[1][2]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined.[2]

References

  1. Cornwall GA, Hann SR (Aug 1995). "Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation". Mol Reprod Dev. 41 (1): 37–46. doi:10.1002/mrd.1080410107. PMID 7619504.
  2. 2.0 2.1 "Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)".

External links

  • The MEROPS online database for peptidases and their inhibitors: I25.027

Further reading

External links




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