CORT

Cortistatin
Identifiers
Symbols	CORT ; CST-14; CST-17; CST-29
External IDs	Template:OMIM5 Template:MGI HomoloGene: 997
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cortistatin, also known as CORT, is a human gene.

The product of this gene is a neuropeptide with strong structural similarity to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin.

Further reading

• Spier AD, de Lecea L (2001). "Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions". Brain Res. Brain Res. Rev. 33 (2–3): 228–41. PMID 11011067.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Puebla L, Mouchantaf R, Sasi R; et al. (1999). "Processing of rat preprocortistatin in mouse AtT-20 cells". J. Neurochem. 73 (3): 1273–7. PMID 10461921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ejeskär K, Abel F, Sjöberg R; et al. (2000). "Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors". Cytogenet. Cell Genet. 89 (1–2): 62–6. PMID 10894940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deghenghi R, Papotti M, Ghigo E, Muccioli G (2001). "Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland". J. Endocrinol. Invest. 24 (1): RC1–3. PMID 11227737.CS1 maint: Multiple names: authors list (link)
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broglio F, Arvat E, Benso A; et al. (2002). "Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans". J. Clin. Endocrinol. Metab. 87 (8): 3783–90. PMID 12161511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dalm VA, van Hagen PM, van Koetsveld PM; et al. (2003). "Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system". J. Clin. Endocrinol. Metab. 88 (1): 270–6. PMID 12519865.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dalm VA, van Hagen PM, van Koetsveld PM; et al. (2003). "Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells". Am. J. Physiol. Endocrinol. Metab. 285 (2): E344–53. doi:10.1152/ajpendo.00048.2003. PMID 12684217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–4. doi:10.1074/jbc.M302456200. PMID 12915402.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papotti M, Tarabra E, Allia E; et al. (2004). "Presence of cortistatin in the human pancreas". J. Endocrinol. Invest. 26 (8): RC15–8. PMID 14669820.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hernández C, Carrasco E, Casamitjana R; et al. (2005). "Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects". Diabetes Care. 28 (8): 1941–7. PMID 16043736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)