COL18A1

Collagen, type XVIII, alpha 1
PDB rendering based on 1bnl.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bnl​
Identifiers
Symbols	COL18A1 ; FLJ27325; KNO; MGC74745
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7673
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Collagen, type XVIII, alpha 1, also known as COL18A1, is a human gene.

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.

See also

Collagen

Further reading

• Pufe T, Kurz B, Petersen W; et al. (2006). "The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system". Ann. Anat. 187 (5–6): 461–72. PMID 16320826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh SP, Kamagata Y, Muragaki Y; et al. (1994). "Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins". Proc. Natl. Acad. Sci. U.S.A. 91 (10): 4229–33. PMID 8183893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh SP, Warman ML, Seldin MF; et al. (1994). "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21". Genomics. 19 (3): 494–9. doi:10.1006/geno.1994.1098. PMID 8188291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sertié AL, Quimby M, Moreira ES; et al. (1996). "A gene which causes severe ocular alterations and occipital encephalocele (Knobloch syndrome) is mapped to 21q22.3". Hum. Mol. Genet. 5 (6): 843–7. PMID 8776601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Reilly MS, Boehm T, Shing Y; et al. (1997). "Endostatin: an endogenous inhibitor of angiogenesis and tumor growth". Cell. 88 (2): 277–85. PMID 9008168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saarela J, Ylikärppä R, Rehn M; et al. (1998). "Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts". Matrix Biol. 16 (6): 319–28. PMID 9503365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ding YH, Javaherian K, Lo KM; et al. (1998). "Zinc-dependent dimers observed in crystals of human endostatin". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10443–8. PMID 9724722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki T, Göhring W, Miosge N; et al. (1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Lett. 460 (2): 280–4. PMID 10544250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Felbor U, Dreier L, Bryant RA; et al. (2000). "Secreted cathepsin L generates endostatin from collagen XVIII". EMBO J. 19 (6): 1187–94. doi:10.1093/emboj/19.6.1187. PMID 10716919.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sertié AL, Sossi V, Camargo AA; et al. (2000). "Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome)". Hum. Mol. Genet. 9 (13): 2051–8. PMID 10942434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rehn M, Veikkola T, Kukk-Valdre E; et al. (2001). "Interaction of endostatin with integrins implicated in angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 1024–9. doi:10.1073/pnas.031564998. PMID 11158588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karumanchi SA, Jha V, Ramchandran R; et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors". Mol. Cell. 7 (4): 811–22. PMID 11336704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Y, Cui LB, Liu CX, Ma QJ (2001). "[Inhibition effect in vitro of purified endostatin expressed in Pichia pastoris]". Sheng Wu Gong Cheng Xue Bao. 17 (3): 278–82. PMID 11517600.CS1 maint: Multiple names: authors list (link)
• Iughetti P, Suzuki O, Godoi PH; et al. (2001). "A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma". Cancer Res. 61 (20): 7375–8. PMID 11606364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu P, Yonekura H, Li H; et al. (2001). "Hypoxia down-regulates endostatin production by human microvascular endothelial cells and pericytes". Biochem. Biophys. Res. Commun. 288 (5): 1149–54. doi:10.1006/bbrc.2001.5903. PMID 11700031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zorick TS, Mustacchi Z, Bando SY; et al. (2002). "High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours". Eur. J. Hum. Genet. 9 (11): 811–4. doi:10.1038/sj.ejhg.5200721. PMID 11781696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanai J, Dhanabal M, Karumanchi SA; et al. (2002). "Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1". J. Biol. Chem. 277 (19): 16464–9. doi:10.1074/jbc.M112274200. PMID 11815623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ergün S, Kilic N, Wurmbach JH; et al. (2002). "Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes". Angiogenesis. 4 (3): 193–206. PMID 11911017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomono Y, Naito I, Ando K; et al. (2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes". Cell Struct. Funct. 27 (1): 9–20. PMID 11937714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.