Bone marrow suppression

(Redirected from Bone marrow depression)
Jump to navigation Jump to search

For congenital bone marrow suppression click here.
For acquired bone marrow suppression click here.
For the main page of bone marrow disorders click here.

WikiDoc Resources for Bone marrow suppression

Articles

Most recent articles on Bone marrow suppression

Most cited articles on Bone marrow suppression

Review articles on Bone marrow suppression

Articles on Bone marrow suppression in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Bone marrow suppression

Images of Bone marrow suppression

Photos of Bone marrow suppression

Podcasts & MP3s on Bone marrow suppression

Videos on Bone marrow suppression

Evidence Based Medicine

Cochrane Collaboration on Bone marrow suppression

Bandolier on Bone marrow suppression

TRIP on Bone marrow suppression

Clinical Trials

Ongoing Trials on Bone marrow suppression at Clinical Trials.gov

Trial results on Bone marrow suppression

Clinical Trials on Bone marrow suppression at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Bone marrow suppression

NICE Guidance on Bone marrow suppression

NHS PRODIGY Guidance

FDA on Bone marrow suppression

CDC on Bone marrow suppression

Books

Books on Bone marrow suppression

News

Bone marrow suppression in the news

Be alerted to news on Bone marrow suppression

News trends on Bone marrow suppression

Commentary

Blogs on Bone marrow suppression

Definitions

Definitions of Bone marrow suppression

Patient Resources / Community

Patient resources on Bone marrow suppression

Discussion groups on Bone marrow suppression

Patient Handouts on Bone marrow suppression

Directions to Hospitals Treating Bone marrow suppression

Risk calculators and risk factors for Bone marrow suppression

Healthcare Provider Resources

Symptoms of Bone marrow suppression

Causes & Risk Factors for Bone marrow suppression

Diagnostic studies for Bone marrow suppression

Treatment of Bone marrow suppression

Continuing Medical Education (CME)

CME Programs on Bone marrow suppression

International

Bone marrow suppression en Espanol

Bone marrow suppression en Francais

Business

Bone marrow suppression in the Marketplace

Patents on Bone marrow suppression

Experimental / Informatics

List of terms related to Bone marrow suppression

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Synonyms and keywords: Bone marrow failure, bone marrow depression, myelosuppression, myelosuppressive disorder

Overview

Bone marrow suppression is the reduction in numbers of cells in the bone marrow, that can be either congenital or acquired. Acquired bone marrow suppression may be any of the following: 1) myelosuppression characterized by a reduction in the number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes), or 2) immunosuppression characterized by a reduction in the number of lymphoid lineage cells (T-cell, B-cell, NK cell). Bone marrow suppression can be a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. NSAIDs may also cause bone marrow suppression. The risk is especially high in chemotherapy for leukemia.

Classification

Shown below is an algorthim that depicts the classification of bone marrow suppression. For congenital bone marrow suppression click here. For acquired bone marrow suppression click here.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Myelodysplasia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
All hematopoietic lineages
 
 
Aplastic anemia (aplastic pancytopenia)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Paroxysmal nocturnal hemoglobinuria (PNH)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Myelosuppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pure red cell aplasia (erythroblastopenia)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
One lineage
 
 
Neutropenia (granulocytopenia and agranulocytosis)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acquired bone marrow suppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Amegakaryocytic thrombocytopenia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
T-cell immunosuppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Immunosuppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
B-cell immunosuppression
 
 
 
 
 
 
 
 
 
 
 
 
 
Bone Marrow Suppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NK cell immunosuppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Multiple lineages
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Congenital bone marrow suppression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
One lineage
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Causes

Drug Side Effects

Natural History, Complications and Prognosis

The bone marrow is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening infection as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as anemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.

Treatment

Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection.

References


Template:WikiDoc Sources