Bilirubin oxidase

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In enzymology, a bilirubin oxidase (EC is an enzyme that catalyzes the chemical reaction

2 bilirubin + O2 2 biliverdin + 2 H2O

Thus, the two substrates of this enzyme are bilirubin and O2, whereas its two products are biliverdin and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is bilirubin:oxygen oxidoreductase. This enzyme is also called bilirubin oxidase M-1. This enzyme participates in porphyrin and chlorophyll metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Murao S and Tanaka N (1981). "A new enzyme bilirubin oxidase produced by Myrothecium verrucaria MT-1". Agric. Biol. Chem. 45: 2383&ndash, 2384.
  • Tanaka N and Murao S (1985). "Reaction of bilirubin oxidase produced by Myrothecium verrucaria MT-1. Agr". Biol. Chem. 49: 843&ndash, 844.

External links

The CAS registry number for this enzyme class is 80619-01-8.

Gene Ontology (GO) codes