Beta-diketone hydrolase

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In enzymology, a beta-diketone hydrolase (EC 3.7.1.7) is an enzyme that catalyzes the chemical reaction

nonane-4,6-dione + H2O pentan-2-one + butanoate

Thus, the two substrates of this enzyme are nonane-4,6-dione and H2O, whereas its two products are pentan-2-one and butanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is nonane-4,6-dione acylhydrolase. This enzyme is also called oxidized PVA hydrolase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J5G and 2J5S.

References

  • IUBMB entry for 3.7.1.7
  • BRENDA references for 3.7.1.7 (Recommended.)
  • PubMed references for 3.7.1.7
  • PubMed Central references for 3.7.1.7
  • Google Scholar references for 3.7.1.7
  • Sakai K, Hamada N and Watanabe Y (1983). "Separation of secondary alcohol oxidase and oxidized poly(vinyl alcohol) hydrolase by hydrophobic and dye-ligand chromatographies". Agric. Biol. Chem. 47: 153&ndash, 155.
  • Sakai K, Hamada N and Watanabe Y (1985). "A new enzyme, beta-diketone hydrolase: a component of a poly(vinyl alcohol)-degrading enzyme preparation". Agric. Biol. Chem. 49: 1901&ndash, 1902.

External links

The CAS registry number for this enzyme class is 97955-12-9.

Gene Ontology (GO) codes


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