Bazin disease overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Bazin disease is a skin ulceration on the back of the calves. It was formerly thought to be a reaction to the tuberculum bacillus. It is very rare now.
Historical Perspective
Bazin disease is named for Pierre-Antoine-Ernest Bazin.[1][2]
Pathophysiology
Bazin disease is a type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis.
Causes
Bazin disease was formerly thought to be a reaction to tuberculum bacillus, but it is now considered a panniculitis that is not associated with a single defined pathogen. [3]
Epidemiology and Demographics
Bazin disease is seen most commonly in adolescent and menopausal women.
Risk Factors
Bazin disease is initiated or exacerbated by cold weather.
Diagnosis
History and Symptoms
50% of patients will have a past or present history of tuberculosis at extracutaneous site. Patients typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves.
Physical Examination
Patients typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves.
References
- ↑ Template:WhoNamedIt
- ↑ P. A. E. Bazin. Leçons théoriques et cliniques sur la scrofule, considérée en ellemême et dans ses rapports avec la syphilis, la dartre et l'arthritis. 2nd edition, Paris, 1861. Page 145 and 501.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. p. 1265. ISBN 0-7216-0187-1.