BMAL

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aryl hydrocarbon receptor nuclear translocator-like
Identifiers
SymbolARNTL
Entrez406
HUGO701
OMIM602550
RefSeqNM_001178
UniProtO00327
Other data
LocusChr. 11 p15
aryl hydrocarbon receptor nuclear translocator-like 2
Identifiers
SymbolARNTL2
Entrez56938
HUGO18984
RefSeqNM_020183
UniProtQ8WYA4
Other data
LocusChr. 12 p12.2-11.2

Bmal (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like) is a gene which encodes proteins regulating circadian rhythm. BMAL proteins form part of a basic-helix-loop-helix transcription factor. BMAL-1 dimerizes with CLOCK in vivo and transactivates gene expression of Period and Timeless in drosophila by binding to E-box elements in their promoters.[1] BMAL1-CLOCK also regulates Cryptochrome genes (e.g. Cry1, Cry2) and Period genes (e.g. Per1, Per2, Per3).[2] Bmal itself is downregulated by Period expression.

See also

References

  1. Ishida N, Kaneko M, Allada R. Biological clocks. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8819-20. [1]
  2. Edery I. Circadian rhythms in a nutshell. Physiol Genomics. 2000 Aug 9;3(2):59-74. [2]

External links


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