BDP1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor TFIIIB component B homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[1][2][3]

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[3]

References

  1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  2. Schramm L, Pendergrast PS, Sun Y, Hernandez N (Nov 2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters". Genes Dev. 14 (20): 2650–63. doi:10.1101/gad.836400. PMC 316990. PMID 11040218.
  3. 3.0 3.1 "Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB".

Further reading

External links