Antistreptolysin O titer

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Antistreptolysin O titre (AS(L)O titre or AS(L)OT) - titre of (serum) antistreptolysin O antibodies; a blood test used to assist in the diagnosis of a streptococcal infection or indicate a past exposure to streptococci.

The ASOT helps direct the antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever and post infectious glomerulonephritis.

A positive test usually is >200 units/mL,[1] but normal ranges vary from laboratory to laboratory and by age.[2]

The false negatives rate is 20-30%.[1] If a false negative is suspected then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.[1]

References

  1. 1.0 1.1 1.2 Antistreptococcal antibody titres. gpnotebook. URL: http://www.gpnotebook.co.uk/cache/-1630535637.htm. Accessed on: March 31, 2007.
  2. Danchin M, Carlin J, Devenish W, Nolan T, Carapetis J (2005). "New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children". J Paediatr Child Health 41 (11): 583-6. PMID 16398843.

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