Aldehyde dehydrogenase (NAD+)

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In enzymology, an aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) is an enzyme that catalyzes the chemical reaction

an aldehyde + NAD+ + H2O an acid + NADH + H+

The 3 substrates of this enzyme are aldehyde, NAD+, and H2O, whereas its 3 products are acid, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD+ oxidoreductase. Other names in common use include CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, and aldehyde dehydrogenase (NAD). This enzyme participates in 17 metabolic pathways: glycolysis / gluconeogenesis, ascorbate and aldarate metabolism, fatty acid metabolism, bile acid biosynthesis, urea cycle and metabolism of amino groups, valine, leucine and isoleucine degradation, lysine degradation, histidine metabolism, tryptophan metabolism, beta-alanine metabolism, glycerolipid metabolism, pyruvate metabolism, 1,2-dichloroethane degradation, propanoate metabolism, 3-chloroacrylic acid degradation, butanoate metabolism, and limonene and pinene degradation.

Structural studies

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes 1A4Z, 1AG8, 1BXS, 1CW3, 1NZW, 1NZX, 1NZZ, 1O00, 1O01, 1O02, 1O04, 1O05, 1O9J, 1OF7, 1OM2, 1ZUM, 2J6L, 2ONM, 2ONN, 2ONO, 2ONP, 2V1S, and 2V1T.

References

  • IUBMB entry for 1.2.1.3
  • BRENDA references for 1.2.1.3 (Recommended.)
  • PubMed references for 1.2.1.3
  • PubMed Central references for 1.2.1.3
  • Google Scholar references for 1.2.1.3
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
  • Racker E (1949). "Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme". J. Biol. Chem. 177: 883&ndash, 892.

External links

The CAS registry number for this enzyme class is 9028-86-8.

Gene Ontology (GO) codes

Template:1.2-enzyme-stub


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