Adrenoleukodystrophy MRI
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Brain MRI may be helpful in the diagnosis of Adrenoleukodystrophy. Findings on MRI suggestive of Adrenoleukodystrophy include Abnormal bright signal intensities on the T2-weighted MRI images, Involvement of Corticospinal tracts is the most common finding in male patients whereas in females there is mild diffuse increase of signal intensity in the parieto occipital or frontal lobe white matter. Spine MRI may also be helpful in the diagnosis of Adrenoleukodystrophy. Findings on MRI suggestive of Adrenoleukodystrophy include Magnetization transfer-weighted (MTw) images showing signal hyperintensities in the lateral and dorsal columns and Diffuse spinal cord atrophy, mainly in the thoracic and cervical regions.
MRI
Brain MRI may be helpful in the diagnosis of Adrenoleukodystrophy. Findings on MRI suggestive of Adrenoleukodystrophy include:
- Abnormal bright signal intensities on the T2-weighted MRI images indicating demyelination of the white matter fibers and tracts.[1]
- Involvement of Corticospinal tracts is the most common finding in male patients whereas in females there is mild diffuse increase of signal intensity in the parieto occipital or frontal lobe white matter.[2]
Spine MRI may be helpful in the diagnosis of Adrenoleukodystrophy. Findings on MRI suggestive of Adrenoleukodystrophy include:
- Magnetization transfer-weighted (MTw) images showing signal hyperintensities in the lateral and dorsal columns.[3]
- Diffuse spinal cord atrophy, mainly in the thoracic and cervical regions. [2]
References
- ↑ Kumar AJ, Rosenbaum AE, Naidu S, Wener L, Citrin CM, Lindenberg R; et al. (1987). "Adrenoleukodystrophy: correlating MR imaging with CT". Radiology. 165 (2): 497–504. doi:10.1148/radiology.165.2.3659373. PMID 3659373.
- ↑ 2.0 2.1 Kumar AJ, Köhler W, Kruse B, Naidu S, Bergin A, Edwin D; et al. (1995). "MR findings in adult-onset adrenoleukodystrophy". AJNR Am J Neuroradiol. 16 (6): 1227–37. PMID 7677014.
- ↑ Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, van Zijl PC; et al. (2005). "Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy". Neurology. 64 (10): 1739–45. doi:10.1212/01.WNL.0000164458.02141.06. PMID 15911801.