Adenylate kinase

Jump to: navigation, search
Adenylate kinase 1
Identifiers
SymbolAK1
Entrez203
HUGO361
OMIM103000
RefSeqNM_000476
UniProtP00568
Other data
EC number2.7.4.3
LocusChr. 9 q34.1

WikiDoc Resources for Adenylate kinase

Articles

Most recent articles on Adenylate kinase

Most cited articles on Adenylate kinase

Review articles on Adenylate kinase

Articles on Adenylate kinase in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Adenylate kinase

Images of Adenylate kinase

Photos of Adenylate kinase

Podcasts & MP3s on Adenylate kinase

Videos on Adenylate kinase

Evidence Based Medicine

Cochrane Collaboration on Adenylate kinase

Bandolier on Adenylate kinase

TRIP on Adenylate kinase

Clinical Trials

Ongoing Trials on Adenylate kinase at Clinical Trials.gov

Trial results on Adenylate kinase

Clinical Trials on Adenylate kinase at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Adenylate kinase

NICE Guidance on Adenylate kinase

NHS PRODIGY Guidance

FDA on Adenylate kinase

CDC on Adenylate kinase

Books

Books on Adenylate kinase

News

Adenylate kinase in the news

Be alerted to news on Adenylate kinase

News trends on Adenylate kinase

Commentary

Blogs on Adenylate kinase

Definitions

Definitions of Adenylate kinase

Patient Resources / Community

Patient resources on Adenylate kinase

Discussion groups on Adenylate kinase

Patient Handouts on Adenylate kinase

Directions to Hospitals Treating Adenylate kinase

Risk calculators and risk factors for Adenylate kinase

Healthcare Provider Resources

Symptoms of Adenylate kinase

Causes & Risk Factors for Adenylate kinase

Diagnostic studies for Adenylate kinase

Treatment of Adenylate kinase

Continuing Medical Education (CME)

CME Programs on Adenylate kinase

International

Adenylate kinase en Espanol

Adenylate kinase en Francais

Business

Adenylate kinase in the Marketplace

Patents on Adenylate kinase

Experimental / Informatics

List of terms related to Adenylate kinase


Overview

Adenylate kinase (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis (see the "Biological homeostasis" section of "Homeostasis"). The reaction catalyzed is:

2 ADPATP + AMP

The equilibrium constant in the direction written is 0.44. Thus, the ΔGo for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of ATP is typically 7-10 times that of ADP, and usually greater than 100 times that of AMP [1]. The rate of oxidative phosphorylation is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep ATP levels high due to the combined action of adenylate kinase and the controls on oxidative phosphorylation.

References

  1. Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.

External links


ca:Mioquinasa de:Adenylat-Kinase



Linked-in.jpg