Adenylate kinase

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Adenylate kinase 1
Identifiers
SymbolAK1
Entrez203
HUGO361
OMIM103000
RefSeqNM_000476
UniProtP00568
Other data
EC number2.7.4.3
LocusChr. 9 q34.1

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Overview

Adenylate kinase (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis (see the "Biological homeostasis" section of "Homeostasis"). The reaction catalyzed is:

2 ADPATP + AMP

The equilibrium constant in the direction written is 0.44. Thus, the ΔGo for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of ATP is typically 7-10 times that of ADP, and usually greater than 100 times that of AMP [1]. The rate of oxidative phosphorylation is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep ATP levels high due to the combined action of adenylate kinase and the controls on oxidative phosphorylation.

References

  1. Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.

External links


ca:Mioquinasa de:Adenylat-Kinase

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