Acute megakaryoblastic leukemia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Differentiating acute megakaryoblastic leukemia from other Diseases

Distinguishing features from other subtypes of AML are following:

Differential Diagnoses:[5]

Acute myeloid leukemia otherwise not specified as per WHO classification:

  1. Acute myeloid leukemia with minimal differentiation
  2. Acute myeloid leukemia without maturation
  3. Acute myeloid leukemia with maturation
  4. Acute myelomonocytic leukemia
  5. Acute monoblastic/monocytic leukemia
  6.  Acute erythroid leukemia
  7. Pure erythroid leukemia
  8. Erythroleukemia, erythroid/myeloid
  9.  Acute basophilic leukemia
  10. Acute panmyelosis with myelofibrosis (a.k.a acute myelofibrosis)

Myeloid sarcoma

References

  1. Zipursky, A.; Thorner, P.; De Harven, E.; Christensen, H.; Doyle, J. (1994). "Myelodysplasia and acute megakaryoblastic leukemia in down's syndrome". Leukemia Research. 18 (3): 163–171. doi:10.1016/0145-2126(94)90111-2. ISSN 0145-2126.
  2. O Olatunji, Philip (2018). "A case of acute megakaryoblastic leukaemia (FAB M7), a rare type of acute myeloid leukemia (AML), in a teenager". Malawi Medical Journal. 30 (4): 298. doi:10.4314/mmj.v30i4.15. ISSN 1995-7262.
  3. Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.
  4. De Marchi, Federico; Araki, Marito; Komatsu, Norio (2019). "Molecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia". Expert Review of Hematology. 12 (5): 285–293. doi:10.1080/17474086.2019.1609351. ISSN 1747-4086.
  5. Döhner, Hartmut; Estey, Elihu H.; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Burnett, Alan K.; Dombret, Hervé; Fenaux, Pierre; Grimwade, David; Larson, Richard A.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J.; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Löwenberg, Bob; Bloomfield, Clara D. (2010). "Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet". Blood. 115 (3): 453–474. doi:10.1182/blood-2009-07-235358. ISSN 0006-4971.

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