Jump to: navigation, search

In enzymology, an acetylesterase (EC is an enzyme that catalyzes the chemical reaction

an acetic ester + H2O an alcohol + acetate

Thus, the two substrates of this enzyme are acetic ester and H2O, whereas its two products are alcohol and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is acetic-ester acetylhydrolase. Other names in common use include C-esterase (in animal tissues), acetic ester hydrolase, chloroesterase, p-nitrophenyl acetate esterase, and Citrus acetylesterase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BS9, 1G66, and 2AXE.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination". Biochem. J. 53: 110&ndash, 7. PMID 13032041.
  • Bergmann F and Rimon S (1960). "Fractionation of C-esterase from the hog's kidney extract". Biochem. J. 77: 209&ndash, 214.
  • Jansen EF, Nutting M-DF and Balls AK (1948). "The reversible inhibition of acetylesterase by diisopropyl fluorophosphate and tetraethyl pyrophosphate". J. Biol. Chem. 175: 975&ndash, 987.

External links

The CAS registry number for this enzyme class is 9000-82-2.

Gene Ontology (GO) codes