DNA repair-deficiency disorder

(Redirected from Accelerated aging disease)
Jump to navigation Jump to search
DNA repair-deficiency disorder
MeSH D049914

WikiDoc Resources for DNA repair-deficiency disorder

Articles

Most recent articles on DNA repair-deficiency disorder

Most cited articles on DNA repair-deficiency disorder

Review articles on DNA repair-deficiency disorder

Articles on DNA repair-deficiency disorder in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on DNA repair-deficiency disorder

Images of DNA repair-deficiency disorder

Photos of DNA repair-deficiency disorder

Podcasts & MP3s on DNA repair-deficiency disorder

Videos on DNA repair-deficiency disorder

Evidence Based Medicine

Cochrane Collaboration on DNA repair-deficiency disorder

Bandolier on DNA repair-deficiency disorder

TRIP on DNA repair-deficiency disorder

Clinical Trials

Ongoing Trials on DNA repair-deficiency disorder at Clinical Trials.gov

Trial results on DNA repair-deficiency disorder

Clinical Trials on DNA repair-deficiency disorder at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on DNA repair-deficiency disorder

NICE Guidance on DNA repair-deficiency disorder

NHS PRODIGY Guidance

FDA on DNA repair-deficiency disorder

CDC on DNA repair-deficiency disorder

Books

Books on DNA repair-deficiency disorder

News

DNA repair-deficiency disorder in the news

Be alerted to news on DNA repair-deficiency disorder

News trends on DNA repair-deficiency disorder

Commentary

Blogs on DNA repair-deficiency disorder

Definitions

Definitions of DNA repair-deficiency disorder

Patient Resources / Community

Patient resources on DNA repair-deficiency disorder

Discussion groups on DNA repair-deficiency disorder

Patient Handouts on DNA repair-deficiency disorder

Directions to Hospitals Treating DNA repair-deficiency disorder

Risk calculators and risk factors for DNA repair-deficiency disorder

Healthcare Provider Resources

Symptoms of DNA repair-deficiency disorder

Causes & Risk Factors for DNA repair-deficiency disorder

Diagnostic studies for DNA repair-deficiency disorder

Treatment of DNA repair-deficiency disorder

Continuing Medical Education (CME)

CME Programs on DNA repair-deficiency disorder

International

DNA repair-deficiency disorder en Espanol

DNA repair-deficiency disorder en Francais

Business

DNA repair-deficiency disorder in the Marketplace

Patents on DNA repair-deficiency disorder

Experimental / Informatics

List of terms related to DNA repair-deficiency disorder

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

An DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair.

It is sometimes considered synonymous with the term accelerated aging disease, which is a genetic disorder in which various tissues, organs or systems of the human body age prematurely. Because the accelerated aging diseases display different aspects of aging, but never every aspect, they are often called segmental progerias by biogerontologists.

This is in contrast to Progeria (Hutchinson-Gilford Progeria syndrome), which affects a broader spectrum of functions.

Examples

Some of the examples include:

Debate concerning "accelerated aging"

Some biogerontologists question that such a thing as "accelerated aging" actually exists, at least partly on the grounds that all of the so-called accelerated aging diseases are segmental progerias. Many disease conditions such as diabetes, high blood pressure, etc. are associated with increased mortality. Without reliable biomarkers of aging it is hard to justify the claim that a disease condition represents more than accelerated mortality[2].

Against this position other biogerontologists argue that premature aging phenotypes are identifiable symptoms associated with mechanisms of molecular damage. The fact that these phenotypes are widely recognized justifies classification of the relevant diseases as "accelerated aging"[3]. Such conditions, it is argued, are readily distinguishable from genetic diseases associated with increased mortality, but not associated with an aging phenotype, such as cystic fibrosis and sickle cell anemia. It is further argued that segmental aging phenotype is a natural part of aging insofar as genetic variation leads to some people being more disposed than others to aging-associated diseases such as cancer and Alzheimer's disease[4].

See also

References

  1. Kleijer WJ, Laugel V, Berneburg M; et al. (2008). "Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy". DNA Repair (Amst.). 7 (5): 744–50. doi:10.1016/j.dnarep.2008.01.014. PMID 18329345. Unknown parameter |month= ignored (help)
  2. Miller RA (2004). "'Accelerated aging': a primrose path to insight?". AGING CELL. 3 (2): 47–51. PMID 15038817.
  3. Hasty P, Vijg J (2004). "Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity". AGING CELL. 3 (2): 55–65. PMID 15038819.
  4. Hasty P, Vijg J (2004). "Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'". AGING CELL. 3 (2): 67–69. PMID 15038820.

External links

Template:Congenital malformations and deformations of integument


Template:WikiDoc Sources