How to read a guideline?

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

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Use the Class designation to indicate whether the therapy is recommended or not and the certainty surrounding that recommendation. Use the Level of Evidence designation to indicate the strength of the data associated with that recommendation.

Class I

Conditions for which there is evidence and/or general agreement that a given procedure or treatment is beneficial, useful, and effective.

Class II

Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a procedure or treatment.

Class IIa

Weight of evidence/opinion is in favor of usefulness/efficacy.

Class IIb

Usefulness/efficacy is less well established by evidence/opinion.

Class III

Conditions for which there is evidence and/or general agreement that a procedure/treatment is not useful / effective and in some cases may be harmful.

Level of Evidence A

Data derived from multiple randomized clinical trials or meta-analyses.

Level of Evidence B

Data derived from a single randomized trial, or non-randomized studies.

Level of Evidence C

Only consensus opinion of experts,case studies, or standard-of-care.

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