APBA2BP

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[1][2]

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[2]

References

  1. Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem. 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507.
  2. 2.0 2.1 "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".

External links

Further reading



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