ANKRD1

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CARP, also known as Cardiac adriamycin-responsive protein or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene.[1][2] CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under conditions of stress. CARP has been implicated in several diseases, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and several skeletal muscle myopathies.

Structure

Human CARP is a 36.2kDa protein composed of 319 amino acids.,[3] though in cardiomyocytes, CARP can exist as multiple alternatively spliced forms.[4] CARP contains five tandem ankyrin repeats. Studies have shown that CARP can homodimerize.[5] Studies have also shown that CARP is N-terminally, post-translationally cleaved by calpain-3 in skeletal muscle, suggesting alternate bioactive forms of CARP exist.[6] CARP has been localized to nuclei and Z-discs in animal and human myocytes, and at intercalated discs in human cells.[7]

Function

CARP was originally identified as a YB-1-associating, cardiac-restricted transcription co-repressor in the homeobox NKX2-5 pathway that is involved in cardiac ventricular chamber specification, maturation and morphogenesis,[8][9][10] and whose mRNA levels are exquisitely sensitive to Doxorubicin, mediated through a hydrogen peroxide/ERK/p38MAP kinase-dependent[11][12] as well as M-CAT cis-element-dependent[13] mechanism. Subsequent studies showed that CARP expression in cardiomyocytes is regulated by alpha-adrenergic signaling, in part via the transcription factor GATA4.[14][15] An additional study showed that beta-adrenergic signaling via protein kinase A and CaM kinase induces the expression of CARP, and that CARP may have a negative effect on contractile function.[16] CARP has also been identified as a transcriptional co-activator of tumor suppressor protein p53 for stimulating gene expression in muscle; p53 was found to be an upstream effector of CARP via upregulation of the proximal ANKRD1 promoter.[17] CARP has a relatively short half-life being longer in cardiomyocytes than endothelial cells; and CARP is degraded by the 26S proteasome via a PEST degron.[18][19]

In animal models of disease and injury, CARP has been characterized to be a stress-inducible myofibrillar protein. CARP has been shown to play a role in skeletal muscle structure[20] remodeling,[21] and repair, being expressed in skeletal muscle near myotendinous junctions,[22] and in vascular smooth muscle cells, as a downstream target of TGF-beta/Smad sigmaling in response to balloon injury[23] and atherosclerotic plaques.[24] Further studies have identified a role for CARP in initiation and regulation of arteriogenesis.[25][26][27] Decreased expression of CARP in cardiac cells within the ischemic region was detected in a rat model of ischemic injury, and was thought to be linked to the induction of GADD153, an apoptosis-related gene.[28] In cardiomyocytes treated with doxorubicin, a model of anthracycline-induced cardiomyopathy, CARP mRNA and protein levels were depleted, myofilament gene transcription was attenuated and sarcomeres showed significant disarray.[29]

In a transgenic mouse model of cardiac-specific overexpression of CARP, mice exhibited normal physiology at baseline, but were protected against pathological cardiac hypertrophy induced via pressure-overload or isoproterenol, which could be attributed to the downregulation of the ERK1/2, MEK and TGFbeta-1 pathways.[30] Another study demonstrated that adenoviral overexpression of CARP in cardiomyocytes enhances cardiac hypertrophy induced by Angiotensin II or pressure-overload[31] and promotoes cardiomyocyte apoptosis via p53 activation and mitochondrial dysfunction.[32] However, transgenic knockout models of either CARP alone or CARP in combination with the other muscle ankyrin repeat proteins (MARPs), ANKRD2 and ANKRD23 demonstrated a lack of cardiac phenotype; mice displayed normal cardiac function at baseline and in response to pressure overload-induced cardiac hypertrophy, suggesting that these proteins are not essential.[33]

Interactions between CARP and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. Passive stretch in fetal cardiomyocytes induced differential CARP distribution at nuclei and I-band titin N2A regions.[34] In a mouse model of muscular dystrophy with myositis (mdm) caused by a small deletion in titin, CARP mRNA expression was shown to be 30-fold elevated in skeletal muscle tissue.[35]

Clinical significance

A wide spectrum of clinical features have been associated with ANKRD1/CARP. Mutations in ANKRD1 have been associated with dilated cardiomyopathy, two of which result in altered binding with TLN1 and FHL2.[36][37] Mutations in ANKRD1 have also been associated with hypertrophic cardiomyopathy, and have shown to increase binding of CARP to Titin and MYPN.[38] Examination of the functional effects of CARP hypertrophic cardiomyopathy mutations in engineered heart tissue demonstrated that Thr123Met was a gain-of-function mutation exhibiting augmented contractile properties; whereas Pro52Ala and Ile280Val were unstable and failed to incorporate into sarcomeres, an effect that was remedied upon proteasome inhibition via epoxomicin.[39]

A missense mutation in ANKRD1 was shown to be associated with the congenital heart defect, Anomalous pulmonary venous connection.[40] CARP has been found as a sensitive and specific biomarker for the differential diagnosis of rhabdomyosarcoma.[41] ANKRD1 mRNA levels correlate with patient platinum sensitivity, thus ANKRD1 associates with platinum-based chemotherapy treatment outcome in ovarian adenocarcinoma patients.[42]

CARP and mRNA expression has been shown to be upregulated in left ventricles of heart failure patients.[43][44][45][46] Studies in patients with amyotrophic lateral sclerosis,[47] spinal muscular atrophy, and congenital myopathy,[48] also found altered expression of CARP in skeletal muscle fibers. Another study in congenital muscular dystrophy and Duchenne muscular dystrophy patients showed elevated expression of CARP.[49] CARP expression is also elevated in patients with lupus nephritis, and associates with proteinuria severity, suggesting that it may have biomarker potential.[50]

Interactions

ANKRD1 has been shown to interact with:

References

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  2. "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)".
  3. "Protein sequence of human ANKRD1 (Uniprot ID: Q15327)". Cardiac Organellar Protein Atlas Knowledgebase. Retrieved 23 June 2015.
  4. Torrado M, Iglesias R, Nespereira B, Centeno A, López E, Mikhailov AT (Jul 2009). "Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium". Gene. 440 (1–2): 28–41. doi:10.1016/j.gene.2009.03.017. PMID 19341785.
  5. 5.0 5.1 Witt SH, Labeit D, Granzier H, Labeit S, Witt CC (2005). "Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling". Journal of Muscle Research and Cell Motility. 26 (6–8): 401–8. doi:10.1007/s10974-005-9022-9. PMID 16450059.
  6. Laure L, Danièle N, Suel L, Marchand S, Aubert S, Bourg N, Roudaut C, Duguez S, Bartoli M, Richard I (Oct 2010). "A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle". The FEBS Journal. 277 (20): 4322–37. doi:10.1111/j.1742-4658.2010.07820.x. PMID 20860623.
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  8. 8.0 8.1 Zou Y, Evans S, Chen J, Kuo HC, Harvey RP, Chien KR (Feb 1997). "CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway". Development. 124 (4): 793–804. PMID 9043061.
  9. Kuo H, Chen J, Ruiz-Lozano P, Zou Y, Nemer M, Chien KR (Oct 1999). "Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis". Development. 126 (19): 4223–34. PMID 10477291.
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  42. Scurr LL, Guminski AD, Chiew YE, Balleine RL, Sharma R, Lei Y, Pryor K, Wain GV, Brand A, Byth K, Kennedy C, Rizos H, Harnett PR, deFazio A (Nov 2008). "Ankyrin repeat domain 1, ANKRD1, a novel determinant of cisplatin sensitivity expressed in ovarian cancer". Clinical Cancer Research. 14 (21): 6924–32. doi:10.1158/1078-0432.CCR-07-5189. PMID 18980987.
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  50. Matsuura K, Uesugi N, Hijiya N, Uchida T, Moriyama M (Mar 2007). "Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis". Human Pathology. 38 (3): 410–9. doi:10.1016/j.humpath.2006.09.006. PMID 17239933.
  51. 51.0 51.1 Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S (November 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. PMID 14583192.
  52. Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S (April 2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". J. Cell Biol. 153 (2): 413–27. doi:10.1083/jcb.153.2.413. PMC 2169455. PMID 11309420.
  53. Torrado M, Nespereira B, López E, Centeno A, Castro-Beiras A, Mikhailov AT (Feb 2005). "ANKRD1 specifically binds CASQ2 in heart extracts and both proteins are co-enriched in piglet cardiac Purkinje cells". Journal of Molecular and Cellular Cardiology. 38 (2): 353–65. doi:10.1016/j.yjmcc.2004.11.034. PMID 15698842.

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