ALS2CR2

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Template:Infobox gene STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.[1][2][3]


This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.[3]


Interactions

ALS2CR2 has been shown to interact with XIAP.[4]

References

  1. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Feb 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. PMID 11161814. doi:10.1006/geno.2000.6392. 
  2. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". J Biol. 2 (4): 28. PMC 333410Freely accessible. PMID 14511394. doi:10.1186/1475-4924-2-28. 
  3. 3.0 3.1 "Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2". 
  4. Sanna, M Germana; da Silva Correia Jean; Luo Ying; Chuang Betty; Paulson Lorien M; Nguyen Binh; Deveraux Quinn L; Ulevitch Richard J (Aug 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. United States. 277 (34): 30454–62. ISSN 0021-9258. PMID 12048196. doi:10.1074/jbc.M203312200. 

External links

Further reading

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