Jump to: navigation, search

Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
PBB Protein AKR1C3 image.jpg
PDB rendering based on 1ry0.
Available structures: 1ry0, 1ry8, 1s1p, 1s1r, 1s2a, 1s2c, 1xf0, 1zq5, 2f38, 2fgb
Symbol(s) AKR1C3; DD3; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS
External IDs OMIM: 603966 MGI2145420 Homologene81636
RNA expression pattern

PBB GE AKR1C3 209160 at tn.png


More reference expression data

Human Mouse
Entrez 8644 105349
Ensembl ENSG00000196139 ENSMUSG00000021214
Uniprot P42330 Q3U538
Refseq NM_003739 (mRNA)
NP_003730 (protein)
NM_134066 (mRNA)
NP_598827 (protein)
Location Chr 10: 5.13 - 5.14 Mb Chr 13: 4.13 - 4.15 Mb
Pubmed search [1] [2]

Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), also known as AKR1C3, is a human gene.[1]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.[1]


Further reading

  • Lin SX, Shi R, Qiu W; et al. (2006). "Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5.". Mol. Cell. Endocrinol. 248 (1-2): 38–46. PMID 16480815. doi:10.1016/j.mce.2005.11.035. 
  • Khanna M, Qin KN, Cheng KC (1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.". J. Steroid Biochem. Mol. Biol. 53 (1-6): 41–6. PMID 7626489. 
  • Khanna M, Qin KN, Wang RW, Cheng KC (1995). "Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.". J. Biol. Chem. 270 (34): 20162–8. PMID 7650035. 
  • Nagase T, Miyajima N, Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
  • Khanna M, Qin KN, Klisak I; et al. (1995). "Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.". Genomics. 25 (2): 588–90. PMID 7789999. 
  • Qin KN, New MI, Cheng KC (1994). "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.". J. Steroid Biochem. Mol. Biol. 46 (6): 673–9. PMID 8274401. 
  • Bennett MJ, Schlegel BP, Jez JM; et al. (1996). "Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.". Biochemistry. 35 (33): 10702–11. PMID 8718859. doi:10.1021/bi9604688. 
  • Lin HK, Jez JM, Schlegel BP; et al. (1998). "Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.". Mol. Endocrinol. 11 (13): 1971–84. PMID 9415401. 
  • Matsuura K, Shiraishi H, Hara A; et al. (1999). "Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.". J. Biochem. 124 (5): 940–6. PMID 9792917. 
  • Mills KI, Gilkes AF, Sweeney M; et al. (1999). "Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells.". FEBS Lett. 440 (1-2): 158–62. PMID 9862446. 
  • Dufort I, Rheault P, Huang XF; et al. (1999). "Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase.". Endocrinology. 140 (2): 568–74. PMID 9927279. 
  • Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.". Cytogenet. Cell Genet. 84 (3-4): 241–2. PMID 10393440. 
  • Griffin LD, Mellon SH (1999). "Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13512–7. PMID 10557352. 
  • Suzuki-Yamamoto T, Nishizawa M, Fukui M; et al. (2000). "cDNA cloning, expression and characterization of human prostaglandin F synthase.". FEBS Lett. 462 (3): 335–40. PMID 10622721. 
  • Nishizawa M, Nakajima T, Yasuda K; et al. (2000). "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.". Genes Cells. 5 (2): 111–25. PMID 10672042. 
  • Penning TM, Burczynski ME, Jez JM; et al. (2001). "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.". Biochem. J. 351 (Pt 1): 67–77. PMID 10998348. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Penning TM, Burczynski ME, Jez JM; et al. (2001). "Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).". Mol. Cell. Endocrinol. 171 (1-2): 137–49. PMID 11165022. 
  • Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMID 11256614. doi:10.1093/embo-reports/kvd058. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899.