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Aldo-keto reductase family 1, member B10 (aldose reductase)
PBB Protein AKR1B10 image.jpg
PDB rendering based on 1zua.
Available structures: 1zua
Symbol(s) AKR1B10; ARL1; HIS; AKR1B11; AKR1B12; ALDRLn; ARL-1; HSI; MGC14103
External IDs OMIM: 604707 MGI107673 Homologene68934
Human Mouse
Entrez 57016 14187
Ensembl na ENSMUSG00000029762
Uniprot na P45377
Refseq NM_020299 (mRNA)
NP_064695 (protein)
NM_008012 (mRNA)
NP_032038 (protein)
Location na Chr 6: 34.28 - 34.3 Mb
Pubmed search [1] [2]

Aldo-keto reductase family 1, member B10 (aldose reductase), also known as AKR1B10, is a human gene.[1]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[1]


Further reading

  • Scuric Z, Stain SC, Anderson WF, Hwang JJ (1998). "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma.". Hepatology. 27 (4): 943–50. PMID 9537432. doi:10.1002/hep.510270408. 
  • Cao D, Fan ST, Chung SS (1998). "Identification and characterization of a novel human aldose reductase-like gene.". J. Biol. Chem. 273 (19): 11429–35. PMID 9565553. 
  • Hyndman DJ, Flynn TG (1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family.". Biochim. Biophys. Acta. 1399 (2-3): 198–202. PMID 9765596. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Crosas B, Hyndman DJ, Gallego O; et al. (2003). "Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.". Biochem. J. 373 (Pt 3): 973–9. PMID 12732097. doi:10.1042/BJ20021818. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Petrovic MG, Peterlin B, Hawlina M, Petrovic D (2005). "Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians.". J. Diabetes Complicat. 19 (2): 70–3. PMID 15745835. doi:10.1016/j.jdiacomp.2004.08.004. 
  • Kang ES, Kim HJ, Paek KS; et al. (2005). "Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.". Cell. Mol. Life Sci. 62 (10): 1146–55. PMID 15928807. doi:10.1007/s00018-005-5024-4. 
  • Lee YS, Paek KS, Kang ES; et al. (2005). "Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.". Int. J. Biochem. Cell Biol. 37 (11): 2297–309. PMID 15936242. doi:10.1016/j.biocel.2005.04.016. 
  • Vikramadithyan RK, Hu Y, Noh HL; et al. (2005). "Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice.". J. Clin. Invest. 115 (9): 2434–43. PMID 16127462. doi:10.1172/JCI24819. 
  • Hazemann I, Dauvergne MT, Blakeley MP; et al. (2005). "High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.". Acta Crystallogr. D Biol. Crystallogr. 61 (Pt 10): 1413–7. PMID 16204895. doi:10.1107/S0907444905024285. 
  • Mashkova TD, Oparina NIu, Zinov'eva OL; et al. (2007). "[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer]". Mol. Biol. (Mosk.). 40 (6): 1047–54. PMID 17209433. 
  • Tammali R, Ramana KV, Srivastava SK (2007). "Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells.". Cancer Lett. 252 (2): 299–306. PMID 17300864. doi:10.1016/j.canlet.2007.01.001. 
  • Yan R, Zu X, Ma J; et al. (2007). "Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention.". Int. J. Cancer. 121 (10): 2301–6. PMID 17597105. doi:10.1002/ijc.22933.