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A kinase (PRKA) anchor protein 8-like
Symbol(s) AKAP8L; DKFZp434L0650; HAP95; NAKAP; NAKAP95
External IDs OMIM: 609475 MGI1860606 Homologene8658
RNA expression pattern

PBB GE AKAP8L 218064 s at tn.png

More reference expression data

Human Mouse
Entrez 26993 54194
Ensembl ENSG00000011243 ENSMUSG00000002625
Uniprot Q9ULX6 Q5RL57
Refseq NM_014371 (mRNA)
NP_055186 (protein)
NM_017476 (mRNA)
NP_059504 (protein)
Location Chr 19: 15.35 - 15.39 Mb Chr 17: 32.05 - 32.08 Mb
Pubmed search [1] [2]

A kinase (PRKA) anchor protein 8-like, also known as AKAP8L, is a human gene.[1]


Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. 
  • Ueki N, Oda T, Kondo M; et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338–42. PMID 9853615. doi:10.1038/4315. 
  • Seki N, Ueki N, Yano K; et al. (2000). "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region.". J. Hum. Genet. 45 (1): 31–7. PMID 10697960. 
  • Westberg C, Yang JP, Tang H; et al. (2000). "A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element.". J. Biol. Chem. 275 (28): 21396–401. PMID 10748171. doi:10.1074/jbc.M909887199. 
  • Orstavik S, Eide T, Collas P; et al. (2000). "Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95.". Biol. Cell. 92 (1): 27–37. PMID 10761695. 
  • Martins SB, Eide T, Steen RL; et al. (2001). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics.". J. Cell. Sci. 113 Pt 21: 3703–13. PMID 11034899. 
  • Yang JP, Tang H, Reddy TR, Wong-Staal F (2001). "Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses.". J. Biol. Chem. 276 (33): 30694–700. PMID 11402034. doi:10.1074/jbc.M102809200. 
  • Wistow G, Bernstein SL, Ray S; et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Martins S, Eikvar S, Furukawa K, Collas P (2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication.". J. Cell Biol. 160 (2): 177–88. PMID 12538639. doi:10.1083/jcb.200210026. 
  • Martins SB, Marstad A, Collas P (2003). "In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling.". Biochemistry. 42 (35): 10456–61. PMID 12950172. doi:10.1021/bi0350699. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086. 
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMID 15302935. doi:10.1073/pnas.0404720101. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Sayer JA, Manczak M, Akileswaran L; et al. (2006). "Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.". Neuromolecular Med. 7 (4): 297–310. PMID 16391387. 
  • Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. PMID 17353931. doi:10.1038/msb4100134.