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Anterior gradient homolog 2 (Xenopus laevis)
Symbol(s) AGR2; AG2; GOB-4; HAG-2; XAG-2
External IDs OMIM: 606358 MGI1344405 Homologene4674
RNA expression pattern

PBB GE AGR2 209173 at tn.png

More reference expression data

Human Mouse
Entrez 10551 23795
Ensembl ENSG00000106541 ENSMUSG00000020581
Uniprot O95994 O88312
Refseq NM_006408 (mRNA)
NP_006399 (protein)
NM_011783 (mRNA)
NP_035913 (protein)
Location Chr 7: 16.8 - 16.81 Mb Chr 12: 36.5 - 36.51 Mb
Pubmed search [1] [2]

Anterior gradient homolog 2 (Xenopus laevis), also known as AGR2, is a human gene.[1]


Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. 
  • Thompson DA, Weigel RJ (1998). "hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines.". Biochem. Biophys. Res. Commun. 251 (1): 111–6. PMID 9790916. doi:10.1006/bbrc.1998.9440. 
  • Petek E, Windpassinger C, Egger H; et al. (2000). "Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation.". Cytogenet. Cell Genet. 89 (3-4): 141–2. PMID 10965104. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Fletcher GC, Patel S, Tyson K; et al. (2003). "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.". Br. J. Cancer. 88 (4): 579–85. PMID 12592373. doi:10.1038/sj.bjc.6600740. 
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. PMID 12690205. doi:10.1126/science.1083423. 
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782. 
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMID 12975309. doi:10.1101/gr.1293003. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. PMID 15340161. doi:10.1110/ps.04682504. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Zhang JS, Gong A, Cheville JC; et al. (2005). "AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer.". Genes Chromosomes Cancer. 43 (3): 249–59. PMID 15834940. doi:10.1002/gcc.20188. 
  • Persson S, Rosenquist M, Knoblach B; et al. (2005). "Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.". Mol. Phylogenet. Evol. 36 (3): 734–40. PMID 15935701. doi:10.1016/j.ympev.2005.04.002. 
  • Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell. 122 (6): 957–68. PMID 16169070. doi:10.1016/j.cell.2005.08.029. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Fritzsche FR, Dahl E, Pahl S; et al. (2006). "Prognostic relevance of AGR2 expression in breast cancer.". Clin. Cancer Res. 12 (6): 1728–34. PMID 16551856. doi:10.1158/1078-0432.CCR-05-2057. 
  • Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032. 
  • Zhang Y, Forootan SS, Liu D; et al. (2007). "Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients.". Prostate Cancer Prostatic Dis. 10 (3): 293–300. PMID 17457305. doi:10.1038/sj.pcan.4500960.