AFREGS Trial
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High Density Lipoprotein Microchapters |
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AFREGS Trial On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Objective
To study the angiographic and clinical effects of increasing HDL levels with pharmacologic treatment.
Methods
The Air Force Regression Study (AFREGS) was a randomized, double- blinded, placebo controlled trial with 143 patients younger than 76 years of age with low HDL levels and angiographically evident coronary artery disease. These patients were randomly allocated to the gemfibrozil, niacin, cholestyramineand corresponding placebo, with aggressive dietary and lifestyle intervention at baseline. They were then followed up for a period of 30 months for clinical events which includes hospitalization for angina, myocardial infarction, transient ischemic attack and stroke, death and other cardiovascular procedures.
Results
- The pharmacologically treated group had a 20% decrease in total cholesterol, 36% increase in HDL cholesterol, 26% decrease in LDL cholesterol and a 50% reduction in triglyceride levels compared to the placebo group.
- Focal coronary stenosis showed an increase of 1.4% in the placebo and a decrease of 0.8% in the drug group.
- 26% of patients in the placebo group reached a composite cardiovascular event end point whereas the same was seen in 13% of patients in the drug group.
Conclusion
Pharmacologic regimens aimed at raising HDL cholesterol levels improved the cholesterol levels, slowed the progression of stenosis, and prevents cardiovascular events in some who exercise regularly and are on a low-fat diet.[1]
References
- ↑ Whitney EJ, Krasuski RA, Personius BE; et al. (2005). "A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events". Annals of Internal Medicine. 142 (2): 95–104. PMID 15657157. Unknown parameter
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