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Template:Infobox gene Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.[1][2]

This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.[2]


  1. Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Adv Hum Genet. 15: 249–90. ISBN 978-1-4615-8358-5. PMID 3006456. doi:10.1007/978-1-4615-8356-1_5. 
  2. 2.0 2.1 "Entrez Gene: ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide". 

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