ADH1A

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Alcohol dehydrogenase 1A (class I), alpha polypeptide
PBB Protein ADH1A image.jpg
PDB rendering based on 1deh.
Available structures: 1deh, 1hdx, 1hdy, 1hdz, 1hso, 1hsz, 1ht0, 1htb, 1u3t, 1u3u, 1u3v, 1u3w, 3hud
Identifiers
Symbol(s) ADH1A; ADH1
External IDs OMIM: 103700 Homologene88335
RNA expression pattern

PBB GE ADH1A 207820 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 124 na
Ensembl ENSG00000187758 na
Uniprot P07327 na
Refseq NM_000667 (mRNA)
NP_000658 (protein)
na (mRNA)
na (protein)
Location Chr 4: 100.42 - 100.43 Mb na
Pubmed search [1] na

Alcohol dehydrogenase 1A (class I), alpha polypeptide, also known as ADH1A, is a human gene.[1]


This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.[1]


References

Further reading

  • Smith M (1986). "Genetics of human alcohol and aldehyde dehydrogenases.". Adv. Hum. Genet. 15: 249–90. PMID 3006456. 
  • Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features.". Biochemistry. 15 (21): 4687–93. PMID 9982. 
  • van Ooij C, Snyder RC, Paeper BW, Duester G (1992). "Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein.". Mol. Cell. Biol. 12 (7): 3023–31. PMID 1620113. 
  • Stewart MJ, McBride MS, Winter LA, Duester G (1990). "Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box.". Gene. 90 (2): 271–9. PMID 2169444. 
  • Yasunami M, Kikuchi I, Sarapata D, Yoshida A (1990). "The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.". Genomics. 7 (2): 152–8. PMID 2347582. 
  • Tsukahara M, Yoshida A (1989). "Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.". Genomics. 4 (2): 218–20. PMID 2737681. 
  • Matsuo Y, Yokoyama S (1989). "Molecular structure of the human alcohol dehydrogenase 1 gene.". FEBS Lett. 243 (1): 57–60. PMID 2920825. 
  • Ikuta T, Szeto S, Yoshida A (1986). "Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.". Proc. Natl. Acad. Sci. U.S.A. 83 (3): 634–8. PMID 2935875. 
  • von Bahr-Lindström H, Höög JO, Hedén LO; et al. (1986). "cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase.". Biochemistry. 25 (9): 2465–70. PMID 3013304. 
  • Duester G, Farrés J, Felder MR; et al. (1999). "Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.". Biochem. Pharmacol. 58 (3): 389–95. PMID 10424757. 
  • Rodriguez-Zavala JS, Weiner H (2002). "Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation.". Biochemistry. 41 (26): 8229–37. PMID 12081471. 
  • Sandberg M, Yasar U, Strömberg P; et al. (2003). "Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase.". British journal of clinical pharmacology. 54 (4): 423–9. PMID 12392591. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Dannenberg LO, Chen HJ, Edenberg HJ (2006). "GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene.". DNA Cell Biol. 24 (9): 543–52. PMID 16153155. doi:10.1089/dna.2005.24.543. 
  • Jelski W, Chrostek L, Szmitkowski M (2007). "The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer.". Pancreas. 35 (2): 142–6. PMID 17632320. doi:10.1097/MPA.0b013e318053eae2. 
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