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Template:Infobox gene Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[1] is an enzyme that in humans is encoded by the ADAM2 gene.[2][3][4]


This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[4] The other subunit is ADAM1 or alpha-fertilin.[1]


  1. 1.0 1.1 Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. PMC 3141649Freely accessible. PMID 21718510. doi:10.1186/1477-7827-9-96. 
  2. Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. PMID 8702389. doi:10.1006/bbrc.1996.1027. 
  3. Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. PMID 9070941. doi:10.1006/geno.1996.4531. 
  4. 4.0 4.1 "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". 

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