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ADAM metallopeptidase domain 2 (fertilin beta)
Symbol(s) ADAM2; CRYN1; CRYN2; FTNB; PH-30b; PH30
External IDs OMIM: 601533 MGI1340894 Homologene1127
RNA expression pattern

PBB GE ADAM2 207664 at tn.png

More reference expression data

Human Mouse
Entrez 2515 11495
Ensembl ENSG00000104755 ENSMUSG00000022039
Uniprot Q99965 Q3TTP6
Refseq NM_001464 (mRNA)
NP_001455 (protein)
NM_009618 (mRNA)
NP_033748 (protein)
Location Chr 8: 39.72 - 39.81 Mb Chr 14: 64.98 - 65.03 Mb
Pubmed search [1] [2]

ADAM metallopeptidase domain 2 (fertilin beta), also known as ADAM2, is a human gene.[1]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[1]


Further reading

  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Eto K, Huet C, Tarui T; et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.". J. Biol. Chem. 277 (20): 17804–10. PMID 11882657. doi:10.1074/jbc.M200086200. 
  • Ikawa M, Nakanishi T, Yamada S; et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.". Dev. Biol. 240 (1): 254–61. PMID 11784061. doi:10.1006/dbio.2001.0462. 
  • Cho C, Ge H, Branciforte D; et al. (2000). "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion.". Dev. Biol. 222 (2): 289–95. PMID 10837118. doi:10.1006/dbio.2000.9703. 
  • Chen MS, Tung KS, Coonrod SA; et al. (1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11830–5. PMID 10518536. 
  • Chen H, Sampson NS (1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta.". Chem. Biol. 6 (1): 1–10. PMID 9889149. doi:10.1016/S1074-5521(99)80015-5. 
  • Burkin HR, Burkin DJ, Davey PM; et al. (1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB).". Genomics. 40 (1): 190–2. PMID 9070941. doi:10.1006/geno.1996.4531. 
  • Vidaeus CM, von Kapp-Herr C, Golden WL; et al. (1997). "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member.". Mol. Reprod. Dev. 46 (3): 363–9. PMID 9041139. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. 
  • Gupta SK, Alves K, Palladino LO; et al. (1996). "Molecular cloning of the human fertilin beta subunit.". Biochem. Biophys. Res. Commun. 224 (2): 318–26. PMID 8702389. doi:10.1006/bbrc.1996.1027. 
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.