Beta-centractin is a protein that in humans is encoded by the ACTR1B gene .[1] [2] [3]
This gene encodes a 42.3 kD subunit of dynactin , a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein . It is involved in a diverse array of cellular functions, including ER -to-Golgi transport, the centripetal movement of lysosomes and endosomes , spindle formation, chromosome movement, nuclear positioning , and axonogenesis . This subunit, like ACTR1A , is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]
References
↑ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins" . Mol Biol Cell . 5 (12): 1301–10. doi :10.1091/mbc.5.12.1301 . PMC 301159 PMID 7696711 . ↑ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet . 84 (1–2): 48–9. doi :10.1159/000015211 . PMID 10343100 . ↑ 3.0 3.1 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)" .
Further reading
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature . 434 (7034): 724–31. doi :10.1038/nature03466 . PMID 15815621 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1" . Mol. Biol. Cell . 14 (7): 2645–54. doi :10.1091/mbc.E03-01-0049 . PMC 165665 PMID 12857853 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature . 355 (6361): 632–4. doi :10.1038/355632a0 . PMID 1538749 .
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