ACTG2

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Actin, gamma 2, smooth muscle, enteric
250px
PDB rendering based on 1atn.
Available structures: 1atn, 1c0f, 1c0g, 1d4x, 1dej, 1eqy, 1esv, 1h1v, 1hlu, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1m8q, 1ma9, 1mdu, 1mvw, 1nlv, 1nm1, 1nmd, 1nwk, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2btf, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hf3, 2hf4, 2hmp, 2oan, 2q1n, 2q31, 2q36
Identifiers
Symbol(s) ACTG2; ACT; ACTA3; ACTE; ACTL3; ACTSG
External IDs OMIM: 102545 Homologene88649
RNA expression pattern

PBB GE ACTG2 202274 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 72 na
Ensembl ENSG00000163017 na
Uniprot P63267 na
Refseq NM_001615 (mRNA)
NP_001606 (protein)
na (mRNA)
na (protein)
Location Chr 2: 73.97 - 74 Mb na
Pubmed search [1] na

Actin, gamma 2, smooth muscle, enteric, also known as ACTG2, is a human gene.[1]


Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.[1]


References

Further reading

  • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639. 
  • Adams LD, Tomasselli AG, Robbins P; et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.". AIDS Res. Hum. Retroviruses. 8 (2): 291–5. PMID 1540415. 
  • Ueyama H (1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG).". Nucleic Acids Res. 19 (2): 411. PMID 1673027. 
  • Miwa T, Manabe Y, Kurokawa K; et al. (1991). "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes.". Mol. Cell. Biol. 11 (6): 3296–306. PMID 1710027. 
  • Tomasselli AG, Hui JO, Adams L; et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279. 
  • Shoeman RL, Kesselmier C, Mothes E; et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease.". FEBS Lett. 278 (2): 199–203. PMID 1991513. 
  • Miwa T, Kamada S (1990). "The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA.". Nucleic Acids Res. 18 (14): 4263. PMID 2377475. 
  • Ueyama H, Inazawa J, Nishino H; et al. (1995). "Chromosomal mapping of the human smooth muscle actin gene (enteric type, ACTA3) to 2p13.1 and molecular nature of the hindIII polymorphism.". Genomics. 25 (3): 720–3. PMID 7759108. 
  • Szucsik JC, Lessard JL (1996). "Cloning and sequence analysis of the mouse smooth muscle gamma-enteric actin gene.". Genomics. 28 (2): 154–62. PMID 8530021. doi:10.1006/geno.1995.1126. 
  • Bukrinskaya A, Brichacek B, Mann A, Stevenson M (1999). "Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.". J. Exp. Med. 188 (11): 2113–25. PMID 9841925. 
  • Zhang H, Wang L, Kao S; et al. (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.". Curr. Biol. 9 (21): 1271–4. PMID 10556093. 
  • Kohnen G, Campbell S, Jeffers MD, Cameron IT (2000). "Spatially regulated differentiation of endometrial vascular smooth muscle cells.". Hum. Reprod. 15 (2): 284–92. PMID 10655297. 
  • Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia.". Gene Expr. 10 (5-6): 201–11. PMID 12450213. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Cheng C, Sharp PA (2003). "RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.". Mol. Cell. Biol. 23 (6): 1961–7. PMID 12612070. 
  • Wu RF, Gu Y, Xu YC; et al. (2004). "Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production.". J. Virol. 78 (2): 779–89. PMID 14694110. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466. 
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