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Acid phosphatase 2, lysosomal
Symbol(s) ACP2;
External IDs OMIM: 171650 MGI87882 Homologene1217
RNA expression pattern

PBB GE ACP2 202767 at tn.png

More reference expression data

Human Mouse
Entrez 53 11432
Ensembl ENSG00000134575 ENSMUSG00000002103
Uniprot P11117 Q3U4F3
Refseq NM_001610 (mRNA)
NP_001601 (protein)
NM_007387 (mRNA)
NP_031413 (protein)
Location Chr 11: 47.22 - 47.23 Mb Chr 2: 91 - 91.01 Mb
Pubmed search [1] [2]

Acid phosphatase 2, lysosomal, also known as ACP2, is a human gene.[1]

Lysosomal acid phosphatase is comprised of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.[1]


Further reading

  • Moss DW, Raymond FD, Wile DB (1995). "Clinical and biological aspects of acid phosphatase.". Critical reviews in clinical laboratory sciences. 32 (4): 431–67. PMID 7576159. 
  • Gierek T, Lisiewicz T, Pilch J (1977). "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx.". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. PMID 69583. 
  • Jones C, Kao FT (1979). "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11.". Hum. Genet. 45 (1): 1–10. PMID 730175. 
  • Shows TB, Brown JA, Lalley PA (1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11.". Cytogenet. Cell Genet. 16 (1-5): 231–4. PMID 975882. 
  • Geier C, von Figura K, Pohlmann R (1989). "Structure of the human lysosomal acid phosphatase gene.". Eur. J. Biochem. 183 (3): 611–6. PMID 2776754. 
  • Lemansky P, Gieselmann V, Hasilik A, von Figura K (1985). "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.". J. Biol. Chem. 260 (15): 9023–30. PMID 3160696. 
  • Pohlmann R, Krentler C, Schmidt B; et al. (1989). "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment.". EMBO J. 7 (8): 2343–50. PMID 3191910. 
  • Waheed A, Van Etten RL (1985). "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells.". Arch. Biochem. Biophys. 243 (1): 274–83. PMID 3904632. 
  • Nadler HL, Egan TJ (1970). "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder.". N. Engl. J. Med. 282 (6): 302–7. PMID 5410815. 
  • Bass DA, Lewis JC, Szejda P; et al. (1981). "Activation of lysosomal acid phosphatase of eosinophil leukocytes.". Lab. Invest. 44 (5): 403–9. PMID 6164873. 
  • Chappard D, Alexandre C, Riffat G (1983). "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies.". Basic and applied histochemistry. 27 (2): 75–85. PMID 6193776. 
  • Moszczyński P, Lisiewicz J (1984). "Beta-glucuronidase of lymphocytes in ontogenetic development of man.". Arch. Immunol. Ther. Exp. (Warsz.). 31 (2): 171–6. PMID 6651479. 
  • Radzun HJ, Parwaresch MR (1981). "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes.". Exp. Hematol. 8 (6): 737–41. PMID 6970673. 
  • Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138. 
  • Whitelock RB, Fukuchi T, Zhou L; et al. (1997). "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. PMID 9040486. 
  • Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Obermüller S, Kiecke C, von Figura K, Höning S (2002). "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.". J. Cell. Sci. 115 (Pt 1): 185–94. PMID 11801736. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504.