ABCC1

Jump to: navigation, search


ATP-binding cassette, sub-family C (CFTR/MRP), member 1
PBB Protein ABCC1 image.jpg
PDB rendering based on 2cbz.
Available structures: 2cbz
Identifiers
Symbol(s) ABCC1; MRP1; ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP
External IDs OMIM: 158343 MGI102676 Homologene55459
RNA expression pattern

PBB GE ABCC1 202804 at tn.png

PBB GE ABCC1 202805 s at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 4363 17250
Ensembl ENSG00000103222 ENSMUSG00000023088
Uniprot P33527 Q3UDM1
Refseq NM_004996 (mRNA)
NP_004987 (protein)
NM_008576 (mRNA)
NP_032602 (protein)
Location Chr 16: 16.01 - 16.14 Mb Chr 16: 14.28 - 14.39 Mb
Pubmed search [1] [2]

ATP-binding cassette, sub-family C (CFTR/MRP), member 1, also known as ABCC1, is a human gene.


The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.[1]


References

Further reading

  • Lautier D, Canitrot Y, Deeley RG, Cole SP (1996). "Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.". Biochem. Pharmacol. 52 (7): 967–77. PMID 8831715. 
  • Deeley RG, Cole SP (1998). "Function, evolution and structure of multidrug resistance protein (MRP).". Semin. Cancer Biol. 8 (3): 193–204. PMID 9441948. doi:10.1006/scbi.1997.0070. 
  • Hegedus T, Orfi L, Seprodi A; et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.". Biochim. Biophys. Acta. 1587 (2-3): 318–25. PMID 12084474. 
  • Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1.". Cancer Metastasis Rev. 26 (1): 15–37. PMID 17295059. doi:10.1007/s10555-007-9041-7. 
</dl>

Linked-in.jpg