ATP-binding cassette, sub-family C (CFTR/MRP), member 1
|PDB rendering based on 2cbz.|
|RNA expression pattern|
ATP-binding cassette, sub-family C (CFTR/MRP), member 1, also known as ABCC1, is a human gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
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- Hegedus T, Orfi L, Seprodi A; et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.". Biochim. Biophys. Acta. 1587 (2-3): 318–25. PMID 12084474.
- Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1.". Cancer Metastasis Rev. 26 (1): 15–37. PMID 17295059. doi:10.1007/s10555-007-9041-7.